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, Volume 21, Issue 1–2, pp 167–172 | Cite as

Comparative studies on the gastrointestinal lesions caused by several nonsteroidal anti-inflammatory agents in rats

  • T. Suwa
  • H. Urano
  • Y. Kohno
  • A. Suzuki
  • T. Amano
Immunosuppression and Inflammation

Abstract

The gastrointestinal toxicity of a single oral administration of five nonsteroidal anti-inflammatory agents (NSAIDs) to rats was compared, by a method using51Cr-labeled red blood cells (RBC), and by macroscopic and microscopic examination. From the profile of gastrointestinal bleeding, the NSAIDs could be divided into a group consisting of aspirin (ASA), oxaprozin (OXP) and 2-[4-(3-methyl-2-butenyl)phenyl]propionic acid (TA), which caused only a transient increase in fecal blood loss based on a gastric lesion, and another group including indomethacin (IM) and ibuprofen (IP), which produced a biphasic increase in the blood loss. The initial phase was caused not only by a gastric lesion but also an intestinal lesion, and the secondary phase originated only in the intestinal lesion. The order of potency causing blood loss was IM≫IP>ASA≫TA>OXP. The safety ratio of OXP and TA was shown to be more favorable than that of the other three drugs.

Keywords

Aspirin Phenyl Blood Loss Indomethacin Ibuprofen 

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Copyright information

© Birkhäuser Verlag 1987

Authors and Affiliations

  • T. Suwa
    • 1
  • H. Urano
    • 1
  • Y. Kohno
    • 1
  • A. Suzuki
    • 1
  • T. Amano
    • 1
  1. 1.Research CenterTaisho Pharmaceutical Co., Ltd.Ohmiya, SaitamaJapan

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