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Antiarrhythmic peptide has no direct cardiac actions

Experientia volume 45, pages 737–738 (1989)Cite this article

Summary

The electrophysiologic, inotropic, and muscarinic effects of antiarrhythmic, peptide (AAP) were examined in canine cardiac Purkinje fibers, ferret papillary muscle, and canine cardiac membranes, respectively. Aside from a prolongation of time to peak force, in papillary muscle, no biologically significant effects of AAP could be determined in any, preparation, suggesting that its antiarrhythmic, effects are not mediated by direct membrane actions.

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Affiliations

  1. Berlex Laboratories, Inc., 110 E. Hanover Ave, 07927, Cedar Knolls, New Jersey, USA

    T. Argentieri, E. Cantor & J. R. Wiggins

Authors
  1. T. Argentieri
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  2. E. Cantor
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  3. J. R. Wiggins
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Argentieri, T., Cantor, E. & Wiggins, J.R. Antiarrhythmic peptide has no direct cardiac actions. Experientia 45, 737–738 (1989). https://doi.org/10.1007/BF01974573

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  • DOI: https://doi.org/10.1007/BF01974573

Key words

  • Cardiac Purkinje fiber
  • electrophysiology
  • ferret
  • dog
  • muscarinic
  • inotropic