, Volume 45, Issue 8, pp 729–730 | Cite as

Antiproliferative effects of 4′, 5′-unsaturated adenine nucleosides on leukemia L 1210 cells in vitro

  • B. Sheid
  • L. M. Lerner
  • E. Gaetjens
Research Articles


Several 4′, 5′-unsaturated adenine nucleosides were shown to have antiproliferative activity against L 1210 leukemia cells in vitro. The active nucleosides were cytotoxic to the L 1210 cells as demonstrated by Trypan Blue uptake. The cytotoxicity was not induced by alterations in the ribonucleoside and deoxyribonucleoside triphosphate levels of the L 1210 cells.

Key words

4′, 5′-unsaturated adenine nucleosides L 1210 leukemia cells cytotoxicity 


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Copyright information

© Birkhäuser Verlag 1989

Authors and Affiliations

  • B. Sheid
    • 1
  • L. M. Lerner
    • 2
  • E. Gaetjens
    • 3
  1. 1.Department of PharmacologyState University of New York, Health Science Center at BrooklynBrooklynUSA
  2. 2.Department of BiochemistryState University of New York, Health Science Center at BrooklynBrooklynUSA
  3. 3.Department of PathologyState University of New York, Health Science Center at BrooklynBrooklynUSA

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