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Prospective study of the impact of broad-spectrum antibiotics on the yeast flora of the human gut

  • G. Samonis
  • A. Gikas
  • P. Toloudis
  • S. Maraki
  • G. Vrentzos
  • Y. Tselentis
  • N. Tsaparas
  • G. Bodey
Notes

Abstract

The effects of four antibiotics on the yeast flora of the human gut were evaluated. Forty adult cancer patients who received therapy with amoxicillin-clavulanate, ciprofloxacin, sulfamethoxazole-trimethoprim or ampicillin were studied prospectively. Quantitative stool cultures for yeasts were performed immediately before, at the end of and one week after the end of the antibiotic treatment. Amoxicillin-clavulanate caused a higher and more persistent increase in gastrointestinal colonization by yeasts compared to ciprofloxacin, sulfamethoxazole-trimethoprim or ampicillin. The present results are similar to those obtained in a mouse model of gastrointestinal colonization byCandida albicans when the same antibiotics were used.

Keywords

Cancer Patient Internal Medicine Mouse Model Ampicillin Antibiotic Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1994

Authors and Affiliations

  • G. Samonis
    • 1
  • A. Gikas
    • 1
  • P. Toloudis
    • 1
  • S. Maraki
    • 2
  • G. Vrentzos
    • 1
  • Y. Tselentis
    • 2
  • N. Tsaparas
    • 1
  • G. Bodey
    • 3
  1. 1.Department of MedicineThe University of Crete, HeraklionCreteGreece
  2. 2.Department of Bacteriology, Parasitology, Zoonoses and Tropical MedicineThe University of Crete, HeraklionCreteGreece
  3. 3.Department of Medical Specialties, Section of Infectious DiseasesThe University of Texas M.D. Anderson Cancer CenterHoustonUSA

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