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, Volume 14, Issue 3–4, pp 534–537 | Cite as

Histamine potentiates neuronal excitation by blocking a calcium-dependent potassium conductance

  • Helmut L. Haas
Histamine in the Central Nervous System

Abstract

Histaminergic neurones send their axons to the whole forebrain. The diffuse projection is consistent with a modulatory role of these pathways. In hippocampal slices from rats a mechanism for this modulation is described, on pyramidal neurones of the CA 1 area: Strong excitations induced by intracellular current injection, ionophoretic administration of glutamate or synaptic stimulation normally restrict themselves by the activation of the calcium-dependent potassium current (gK(Ca)). This current causes a long lasting afterhyperpolarization and an accommodation of firing. Their block by histamine and impromidine (reversed by metiamide and cimetidine) leads to a profound potentiation of excitatory signals. It is suggested that HA, through H2 receptors, accelerates the removal of intracellular free Ca++ ions.

Keywords

Glutamate Histamine Cimetidine Pyramidal Neurone Hippocampal Slice 

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Copyright information

© Birkhäuser Verlag 1984

Authors and Affiliations

  • Helmut L. Haas
    • 1
  1. 1.Neurochirurgische UniversitätsklinikZürichSwitzerland

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