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, Volume 14, Issue 3–4, pp 534–537 | Cite as

Histamine potentiates neuronal excitation by blocking a calcium-dependent potassium conductance

  • Helmut L. Haas
Histamine in the Central Nervous System

Abstract

Histaminergic neurones send their axons to the whole forebrain. The diffuse projection is consistent with a modulatory role of these pathways. In hippocampal slices from rats a mechanism for this modulation is described, on pyramidal neurones of the CA 1 area: Strong excitations induced by intracellular current injection, ionophoretic administration of glutamate or synaptic stimulation normally restrict themselves by the activation of the calcium-dependent potassium current (gK(Ca)). This current causes a long lasting afterhyperpolarization and an accommodation of firing. Their block by histamine and impromidine (reversed by metiamide and cimetidine) leads to a profound potentiation of excitatory signals. It is suggested that HA, through H2 receptors, accelerates the removal of intracellular free Ca++ ions.

Keywords

Glutamate Histamine Cimetidine Pyramidal Neurone Hippocampal Slice 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag 1984

Authors and Affiliations

  • Helmut L. Haas
    • 1
  1. 1.Neurochirurgische UniversitätsklinikZürichSwitzerland

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