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, Volume 14, Issue 3–4, pp 315–318 | Cite as

Neuronally mediated non-cholinergic contraction of guineapig bronchial smooth muscle is inhibited by a substance P antagonist

  • S. Leander
  • N. Grundström
  • R. G. G. Andersson
  • R. Håkanson


The isolated main bronchi of the guinea-pig respond to electrical field stimulation with a twitch followed by a slow contraction. Atropine blocked the slow contraction. The substance P antagonist, (d-Pro2,d-Trp7.9)-SP, greatly reduced the atropine-resistant contraction. The results suggest the involvement of substance P in non-cholinergic neurotransmission in the guinea-pig airways.


Smooth Muscle Atropine Main Bronchus Electrical Field Stimulation Field Stimulation 
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Copyright information

© Birkhäuser Verlag 1984

Authors and Affiliations

  • S. Leander
    • 1
  • N. Grundström
    • 2
  • R. G. G. Andersson
    • 2
  • R. Håkanson
    • 1
  1. 1.Department of PharmacologyUniversity of LundLundSweden
  2. 2.Department of PharmacologyUniversity of LinköpingLinköpingSweden

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