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, Volume 14, Issue 3–4, pp 315–318 | Cite as

Neuronally mediated non-cholinergic contraction of guineapig bronchial smooth muscle is inhibited by a substance P antagonist

  • S. Leander
  • N. Grundström
  • R. G. G. Andersson
  • R. Håkanson


The isolated main bronchi of the guinea-pig respond to electrical field stimulation with a twitch followed by a slow contraction. Atropine blocked the slow contraction. The substance P antagonist, (d-Pro2,d-Trp7.9)-SP, greatly reduced the atropine-resistant contraction. The results suggest the involvement of substance P in non-cholinergic neurotransmission in the guinea-pig airways.


Smooth Muscle Atropine Main Bronchus Electrical Field Stimulation Field Stimulation 


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  1. [1]
    N. Grundström, R.G.G. Andersson andJ.E.S. Wikberg,Pharmacological characterization of the autonomous innervation of the guinea-pig tracheobronchial smooth muscle, Acta pharmac. tox.49, 150–157 (1981).Google Scholar
  2. [2]
    G. Nilsson, K. Dahlberg, E. Brodin, F. Sundler andK. Strandberg, Distribution and constrictor effects of substance P in guinea-pig tracheobronchial tissue. InSubstance P, pp. 57–81 (Ed.U.S. von Euler andB. Pernow). Raven Press, New York 1977.Google Scholar
  3. [3]
    R. Uddman, J. Alumets, O. Densert, R. Håkanson andF. Sundler,Occurrence and distribution of VIP nerves in the nasal mucosa and tracheo-bronchial wall, Acta otolar.86, 443–448 (1978).Google Scholar
  4. [4]
    M.A. Ghatei, M.N. Sheppard, D.J. O'Shaughnessy, T.E. Adrian, G.P. McGregor, J.M. Polak andS.R. Bloom,Regulatory peptides in the mammalian respiratory tract, Endocrinology111, 1248–1254 (1982).PubMedGoogle Scholar
  5. [5]
    R. Håkanson, F. Sundler, E. Moghimzadeh andS. Leander,Peptide-containing nerve fibres in the airways: Distribution and functional implications, Eur. J. Resp. Dis., in press (1983).Google Scholar
  6. [6]
    S. Leander, R. Håkanson, S. Rosell, K. Folkers, F. Sundler andT. Tornqvist,A specific substance P antagonist blocks smooth muscle contractions induced by non-cholinergic, non-adrenergic nerve stimulation, Nature, Lond.294, 467–469 (1981).Google Scholar
  7. [7]
    R. Håkanson, J. Hörig andS. Leander,The mechanism of action of a substance P antagonist (d-Pro 2,d-Trp 7,9)-SP, Br. J. Pharmac.77, 697–700 (1982).Google Scholar
  8. [8]
    C.Y. Kao,Tetrodotoxin, saxitoxin and their significance in the study of excitation phenomena, Pharmac. Rev.18, 997–1049 (1966).Google Scholar
  9. [9]
    J.M. Lundberg andA. Saria,Bronchial smooth muscle contraction induced by stimulation of capsaicinsensitive sensory neurons, Acta physiol. scand.116, 473–476 (1982).PubMedGoogle Scholar
  10. [10]
    R. Håkanson, S. Leander, R.G.G. Andersson andJ. Hörig,Substance P antagonists release histamine from peritoneal mast cells, Acta physiol. scand.,117, 319–320 (1983).PubMedGoogle Scholar
  11. [11]
    W. Lorenz, M. Thermann, H. Hamelmann, A. Schmal, D. Maroske, H.-J. Reimann, J. Kusche, F. Schingale, P. Dormann andP. Keck, Influence of H1- and H2-receptor antagonists on the effects of histamine in the circulatory system and on plasma histamine levels. InInternational Symposium on Histamine H 2-receptor Antagonists, pp. 151–163 (Eds.C.J. Wood andM.A. Simkins). Deltakos, London 1973.Google Scholar

Copyright information

© Birkhäuser Verlag 1984

Authors and Affiliations

  • S. Leander
    • 1
  • N. Grundström
    • 2
  • R. G. G. Andersson
    • 2
  • R. Håkanson
    • 1
  1. 1.Department of PharmacologyUniversity of LundLundSweden
  2. 2.Department of PharmacologyUniversity of LinköpingLinköpingSweden

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