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, Volume 14, Issue 3–4, pp 315–318 | Cite as

Neuronally mediated non-cholinergic contraction of guineapig bronchial smooth muscle is inhibited by a substance P antagonist

  • S. Leander
  • N. Grundström
  • R. G. G. Andersson
  • R. Håkanson
Article

Abstract

The isolated main bronchi of the guinea-pig respond to electrical field stimulation with a twitch followed by a slow contraction. Atropine blocked the slow contraction. The substance P antagonist, (d-Pro2,d-Trp7.9)-SP, greatly reduced the atropine-resistant contraction. The results suggest the involvement of substance P in non-cholinergic neurotransmission in the guinea-pig airways.

Keywords

Smooth Muscle Atropine Main Bronchus Electrical Field Stimulation Field Stimulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag 1984

Authors and Affiliations

  • S. Leander
    • 1
  • N. Grundström
    • 2
  • R. G. G. Andersson
    • 2
  • R. Håkanson
    • 1
  1. 1.Department of PharmacologyUniversity of LundLundSweden
  2. 2.Department of PharmacologyUniversity of LinköpingLinköpingSweden

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