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Archives of Toxicology

, Volume 67, Issue 2, pp 141–144 | Cite as

Investigation of possible metabolism of Pigment Yellow 17, a 3,3′-dichlorobenzidine-based pigment, after inhalation exposure in rats

  • Thomas Hofmann
  • Dietmar Schmidt
Short Communication

Abstract

Rats were exposed by inhalation to the technically highest administrable concentration of 230 mg Pigment Yellow 17/m3 air for 4 h. Inhalability of the dust was guaranteed by a mass-median aerodynamic diameter of 1.0–1.1 μm. For 14 days after exposure, urine and serum samples were analysed for 3,3′-dichlorobenzidine, the parent carcinogenic amine of the test compound. No 3,3′-dichlorobenzidine could be detected either in urine or blood, the detection limit being 5 ng/ml for both media. Based on the results of this study there is no evidence for metabolic cleavage of Pigment Yellow 17 to 3,3′-dichlorobenzidine in the rat.

Key words

Pigment Yellow 17 3,3′-Dichlorobenzidine Biotransformation Gas chromatography 

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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • Thomas Hofmann
    • 1
  • Dietmar Schmidt
    • 1
  1. 1.Pharma Entwicklung ToxikologieHoechst AktiengesellschaftFrankfurt/Main 80Germany

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