Archives of Toxicology

, Volume 66, Issue 5, pp 365–367 | Cite as

Activity of glutathione-S-transferase in rat liver and kidneys after administration of lead or cadmium

  • Felicitas Planas-Bohne
  • Montserrat Elizalde
Short Communication


The influence of an acute dose of lead nitrate or cadmium chloride on the activity of glutathione-S-trans-ferase (GST) was investigated in rats. CdCl2 (10 Μmol/kg) did not influence the enzyme activity in either organ. In contrast Pb(NO3)2 (100 Μmol/kg) caused a significant increase of GST activity in both organs. SDS polyacrylamide gel electrophoresis (SDS-PAGE) showed that in liver the activity enhancement is due mainly to the induction of the isoenzyme GST 7-7, while in the kidneys the activity of all the isoenzymes is increased.

Key words

Glutathione-S-transferase Rats Lead Cadmium 


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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • Felicitas Planas-Bohne
    • 1
  • Montserrat Elizalde
    • 1
  1. 1.Institut für Genetik und ToxikologieKernforschungszentrum KarlsruheKarlsruheGermany

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