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Archives of Toxicology

, Volume 64, Issue 5, pp 412–413 | Cite as

Effects of CGS 9896 in acute experimental intoxication with fluostigmine

  • S. Rump
  • W. Raszewski
  • T. Gidynska
  • E. Galecka
Short Communication

Abstract

The therapeutic effectiveness of CGS 9896, a novel potent anxiolytic and anticonvulsant, in organophosphate intoxication was studied. It was demonstrated that this drug, used as an adjunct to a mixture of atropine and obidoxime, led to a rise in the LD50 of fluostigmine in mice of more than 150 times and more than 138 times for 2 and 24 h, respectively. After 24 h, this effect was twice that of diazepam, which served as a reference drug.

Key words

CGS 9896 Fluostigmine Organophosphates 

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • S. Rump
    • 1
  • W. Raszewski
    • 1
  • T. Gidynska
    • 1
  • E. Galecka
    • 1
  1. 1.Department of Pharmacology and ToxicologyMilitary Institute of Hygiene and EpidemiologyWarsawPoland

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