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Archives of Toxicology

, Volume 64, Issue 4, pp 343–344 | Cite as

Detection of diepoxybutane-induced DNA-DNA crosslinks by cesium trifluoracetate (CsTFA) density-gradient centrifugation

  • C. Ristau
  • S. Deutschmann
  • R. J. Laib
  • H. Ottenwälder
Letter to the Editor

Keywords

Centrifugation Cancer Research Cesium Trifluoracetate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

DDC

DNA-DNA crosslinks

CsTFA

Cesiumtrifluoracetate

BD

butadiene

DEB

diepoxybutane

References

  1. Carter C, Britton VJ, Haff L (1983) CsTFA™: a centrifugation medium for nucleic acid isolation and purification. In: Biotechniques, pp 142–146Google Scholar
  2. Jelitto B, Vangala RR, Laib RJ (1989) Species differences in DNA damage by butadiene: Role of diepoxybutane. Arch Toxicol Suppl 13: 246–249PubMedGoogle Scholar
  3. Kohn KW, Spears CL, Doty P (1966) Inter-strand crosslinking of DNA by nitrogen mustard. J Mol Biol 19: 266–288PubMedGoogle Scholar
  4. Kreiling R, Laib RJ, Bolt HM (1986) Alkylation of nuclear proteins and DNA after exposure of rats and mice to 1,4−14-C 1,3-butadiene. Toxicol Lett 30: 131–135PubMedGoogle Scholar
  5. Laib RJ, Deutschmann S, Jelitto B, Vangala RR, Kreiling R (1989) Species differences in pharmacokinetics, metabolism, and DNA binding of inhaled 1,3-butadiene. In: Mohr et al. (eds) Assessment of inhalation hazards: integration and extrapolation using diverse data. Springer-Verlag, New York, pp 189–199Google Scholar
  6. Lawley PD, Brookes P (1967) Interstrand cross-linking of DNA by bifunctional alkylating agents. J Mol Biol 25: 143–160PubMedGoogle Scholar
  7. Malvoisin E, Robertfroid M (1982) Hepatic microsomal (metabolism of 1,3-butadiene. Xenobiotica 12: 137–144PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • C. Ristau
    • 1
  • S. Deutschmann
    • 1
  • R. J. Laib
    • 1
  • H. Ottenwälder
    • 1
  1. 1.Institut für Arbeitsphysiologie and der Universität DortmundDortmund 1Federal Republic of Germany

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