Abstract
The prevalence and antigen specificity of anti-neutrophil cytoplasmic antibodies (ANCA) in sera from 23 children with active systemic lupus erythematosus (SLE) were studied utilizing indirect immunofluorescence and IgG and IgM ELISA using crude neutrophil extract and purified proteinase 3, myeloperoxidase, lactoferrin, cathepsin G and elastase. ANCA were present in 69% of SLE children and consisted of IgM and IgG antibodies of variable specificities, but did not correlate with organ involvement or disease activity. It remains unclear whether they have pathogenic significance or are epiphenomena in the category of polyclonal B-cell activation. However, their presence is entirely compatible with SLE even though they have hitherto been commonly associated with other systemic vasculitides.
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Abbreviations
- ANCA :
-
antineutrophil cytoplasmic antibodies
- C-ANCA :
-
ANCA measured by IIF showing a cytoplasmic staining pattern
- CATH :
-
cathepsin G
- CATH-IgG or IgM :
-
IgG or IgM ANCA reacting with cathepsin G
- CNE :
-
crude neutrophil extract
- ELAS :
-
elastase
- ELAS-IgG or IgM :
-
IgG or IgM ANCA reacting with elastase
- IIF :
-
indirect immunofluorescence microscopy
- LACT :
-
lactoferrin
- LACT-IgG or IgM :
-
IgG or IgM ANCA reacting with lactoferrin
- MPO :
-
myeloperoxidase
- MPO-IgG or IgM :
-
IgG or IgM ANCA reacting with myeloperoxidase
- P-ANCA :
-
ANCA measured by IIF showing a perinuclear staining pattern
- PR3 :
-
proteinase 3
- PR3-IgG :
-
IgG ANCA reacting with proteinase 3
- SLE :
-
systemic lupus erythematosus
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Wong, S.N., Shah, V. & Dillon, M.J. Anti-neutrophil cytoplasmic antibodies in childhood systemic lupus erythematosus. Eur J Pediatr 154, 43–45 (1995). https://doi.org/10.1007/BF01972971
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DOI: https://doi.org/10.1007/BF01972971