Abstract
A beclomethasone dipropionate (BDP) enema and a BDP/mesalazine combination enema (containing 2 mg BDP and 1 g mesalazine and 2 mg BDP, respectively per 40 ml) were formulated. BDP and mesalazine were suspended in a carbomer-water gel. No degradation of BDP was measured during the storage period of the BDP enema (4 weeks at 20°C) and of the BDP/mesalazine enema (44 days at 4°C, 20°C and 37°C, respectively). Progressive darkening of colour occurred for the BDP/mesalazine enema during storage at 20°C and at 37°C, probably induced by mesalazine degradation products. Only very slight colouring was observed at 4°C. Hardly any precipitation of BDP and mesalazine was seen during the storage period and the enemas could easily be resuspended.
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Kumana CR, Meghji M, Seaton T, Castelli M, Benson R, Sivakumaran T. Beclomethasone dipropionate enemas for treating inflammatory bowel disease without producing Cushings syndrome or hypothalamic pituitary adrenal suppression. Lancet 1982;1:579–83.
Bansky G, Bühler H, Stamm B, Häcki W, Buchmann P, Müller J. Treatment of distal ulcerative colitis with beclomethasone enemas: high therapeutic efficacy without endocrine side effects. Dis Col Rect 1987;30:288–92.
Van der Heide H, Van den Brandt-Gradel V, Tytgat GNJ, et al. Comparison of beclomethasone dipropionate and prednisolone 21-phosphate enemas in the treatment of ulcerative proctitis. J Clin Gastroenterol 1988;10(2):169–72.
Van der Heide H, Mulder CJJ, Wiltink EHH, Endert E, Houthoff HJ, Tytgat GNJ. Comparison of enemas containing beclomethasone dipropionate (BDP) and prednisolone 21-phosphate (PP) in the treatment of distal ulcerative colitis [Abstract]. Gastroenterology 1987;92:1679.
Mulder CJJ, Tytgat GNJ, Wiltink EHH, Houthoff HJ. Comparison of 5-aminosalicylic acid (3 g) and prednisolone phosphate sodium enemas (30 mg) in the treatment of distal ulcerative colitis. Scand J Gastroenterol 1988;23:1005–8.
Montgomery HA, Smith FM, Scott BE, White SJ, Gerald KB. Stability of 5-aminosalicylic acid suspension. Am J Hosp Pharm 1986;43:118–20.
Dolder R, Quinke K, Wah K. Clysma acidi metaminosalicylici. Krankenhauspharmazie 1981;2:123–6.
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Stolk, L.M.L., Gerrits, M., Wiltink, E.H.H. et al. Formulation and stability of a beclomethasone dipropionate enema. Pharmaceutisch Weekblad Scientific Edition 11, 20–22 (1989). https://doi.org/10.1007/BF01972910
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DOI: https://doi.org/10.1007/BF01972910