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, Volume 27, Issue 3–4, pp 435–437 | Cite as

Evidence of free radical (FR) involvement in ischemic colitis

  • D. M. Douglas
  • J. C. Russell
  • D. Goren
  • S. Dempsey
  • D. K. Das
Mediation of Inflammatory Process

Abstract

Early ischemic colitis was induced in rats to evaluate the roles of FRs and intraluminal content. After 30 minutes of ischemia, biopsies for histology, conjugated dienes (CD) and malonaldehyde (M), presumptive marker of lipid peroxidation, were obtained at 0, 30, and 60 minutes reperfusion. Histology was unchanged. CD and M were elevated in ischemic and saline controls, and rose progressively during reperfusion; CD and M were essentially the same as non-ischemic controls during reperfusion with intraluminal corticosteroid (c) and Alcide (A). These agents may be beneficial in early ischemic colitis.

Keywords

Lipid Ischemia Corticosteroid Free Radical Lipid Peroxidation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag 1989

Authors and Affiliations

  • D. M. Douglas
    • 1
  • J. C. Russell
    • 1
  • D. Goren
    • 1
  • S. Dempsey
    • 1
  • D. K. Das
    • 1
  1. 1.Department of SurgeryUniversity of Connecticut School of MedicineFarmingtonUSA

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