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, Volume 27, Issue 3–4, pp 335–337 | Cite as

Inhibition of autoimmune disease and the generation of suppressor cells by spirogermanium: A biological profile similar to total lymphoid irradiation

  • A. M. Badger
  • C. K. Mirbelli
  • B. A. Swift
  • M. J. DiMartino
Animal Models


Oral administration of spirogermanium (Sg), inhibits the development of immune-mediated hindpaw inflammation in the rat model of adjuvant arthritis (AA) and DTH responses to PPD (30 mg/kg/day). A similar dosing protocol inhibits hindleg paralysis in experimental autoimmune encephalomyelitis (EAE). The spleens of these animals and those of normal rats contain radiation resistant (2000 R) non-specific suppressor cells (SC) which bear some similarity to those generated following total lymphoid irridiation (TLI). These cells do not appear to be mature T cells, they are partially adherent to plastic, sephadex G10 and nylon wool, insensitive to indomethacin and are enriched in a 1.07 g/ml fraction of a Percoll density gradient.


Nylon Oral Administration Indomethacin Density Gradient Experimental Autoimmune Encephalomyelitis 
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Copyright information

© Birkhäuser Verlag 1989

Authors and Affiliations

  • A. M. Badger
    • 1
  • C. K. Mirbelli
    • 1
  • B. A. Swift
    • 1
  • M. J. DiMartino
    • 1
  1. 1.Smith Kline and French LaboratoriesKing of PrussiaUSA

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