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, Volume 27, Issue 3–4, pp 282–284 | Cite as

Interleukin-1 mediated signal transduction associated with synovial cell activation

  • E. Mochan
  • B. Ross
  • R. Sporer
  • J. Uhl
Cytokines

Abstract

The early biochemical events that link interleukin-1 (IL-1) receptor occupancy to neutral proteinase production in synovial cells were studied. Addition of human r-IL-1 to human synovial cells in culture stimulated phospholipase A2 (PLA2) activity, inositol trisphosphate production and plasminogen activator (PA) activity in a dose dependent manner with similar EC50 values (0.1–0.5nM). These results, coupled with time courses and other studies, suggest that the IL-1 modulation of PA involves both products of PLA2 and phospholipase C (PLC) activation. On the other hand, the IL-1 induction of collagenase may primarily involve PLC and protein kinase C activation.

Keywords

Plasminogen Activator Collagenase Inositol Mediate Signal Biochemical Event 

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References

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Copyright information

© Birkhäuser Verlag 1989

Authors and Affiliations

  • E. Mochan
    • 1
  • B. Ross
    • 1
  • R. Sporer
    • 1
  • J. Uhl
    • 2
  1. 1.Department of Family Medicine and BiochemistryUniversity of Medicine and Dentistry of New Jersey, School of Osteopathic MedicineCamdenUSA
  2. 2.Drug DeliverySterling Drug Inc.Great ValleyUSA

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