Advertisement

Agents and Actions

, Volume 39, Supplement 1, pp C102–C103 | Cite as

Coagulation effects of cyclosporine in liver transplantation

  • R. J. Ferrante
  • C. R. Spillert
  • D. J. Wilson
  • E. J. Lazaro
Immunoregulation

Abstract

Thromboembolic complications have been described in graft recipients receiving cyclosporine (CS). Whether these individuals have a hypercoagulable state when compared to healthy controls was evaluated. Recalcification times (RT) of saline-incubated citrated whole blood and endotoxin-incubated whole blood of both control and transplant patients were determined. There was no difference between the RT saline or RT endotoxin groups in both patient groups. These data suggest that CS alone has no procoagulant effects, but that addtional factors such as endotoxin and/or graft-induced antigen production may provoke the thrombotic complications.

Keywords

Citrate Patient Group Cyclosporine Liver Transplantation Transplant Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. [1]
    C. J. Bruce, C. R. Spillert, D. J. Wilson, C. A. Schneider and E. J. Lazaro,Is endotoxin, not cyclosporine responsible for post-transplant hypercoagulability?. Southeastern Surgical Congress, Atlanta, GA, 1992.Google Scholar
  2. [2]
    C. R. Spillert and E. J. Lazaro,Contribution of the monocyte to thrombotic potential. Agents and Actions34, 28–29 (1991).CrossRefPubMedGoogle Scholar
  3. [3]
    C. R. Spillert, M. R. Passannante, J. E. Salzer-Pagan and E. J. Lazaro,Altered coagulability: An aid to selective breast biopsy. J. Natl. Med. Assoc. 1993; 85: 273–277.PubMedGoogle Scholar
  4. [4]
    C. R. Spillert and E. J. Lazaro,Modified recalcification time: A global coagulation screening test. J. Natl. Med. Assoc. (in press).Google Scholar

Copyright information

© Birkhäuser Verlag 1993

Authors and Affiliations

  • R. J. Ferrante
    • 1
  • C. R. Spillert
    • 1
  • D. J. Wilson
    • 1
  • E. J. Lazaro
    • 1
    • 2
  1. 1.Department of SurgeryUMDNJ-New Jersey Medical School (G505)NewarkUSA
  2. 2.Department of AnatomyUMDNJ-New Jersey Medical School (G505)NewarkUSA

Personalised recommendations