Pharmacological mediators of various immunological and non-immunological inflammatory reactions produced in the pleural cavity
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Intrapleural exudates have been produced in rats and guinea-pigs using calcium pyrophosphate, cell mediated immunity, reversed passive Arthus reaction and carrageenan. The intracellular concentration of various pharmacological mediators has been measured at different times during the evolution of these inflammatory responses. These have been correlated with volume of exudate and cellular migration.
The significance of these findings has been discussed and the possible application to the search for new anti-inflammatory agents and their use in diagnostic procedures.
KeywordsCalcium Inflammatory Response Diagnostic Procedure Inflammatory Reaction Pyrophosphate
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- D.A. Willoughby,Human Arthritis Applied to Animal Models: Towards a Better Therapy, Ann. rheum. Dis., in press (1975).Google Scholar
- S. Yamamoto, C.J. Dunn, D.A. Deporter, E.C. Huskisson andD.A. Willoughby,A Model for the Study of Immediate Hypersensitivity in Rats, Agents and Actions, submitted for publication (1975).Google Scholar
- W.G. Spector andD.A. Willoughby, in:The Pharmacology of Inflammation (English Universities Press, London 1968).Google Scholar
- P. Crunkhorn andA.L. Willis,Cutaneous Reactions to Intradermal Prostaglandins, Br. J. Pharmac.41, 49 (1971).Google Scholar
- B. Samuelsson,On the Formation and Properties of an Endoperoxide Intermediate in Prostaglandin Biosynthesis, in:Future Trends in Inflammation (Eds. G.P. Velo, D.A. Willoughby, J.P. Giroud; Piccin Medical Books, Padua and London 1974), p. 5.Google Scholar