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Effect of bilateral nephrectomy on serum gastrin concentration, gastric histamine content, histidine decarboxylase activity and acid secretion in the rat

  • Models in Toxicology
  • Abstracts of other papers given at the `4th Annual Meeting of the European Branch of the Histamine Club', Florence 5–6 June 1975
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Conclusion

In the nephrectomized rat gastrin (and pentagastrin) does not evoke acid secretion but retains its ability to activate gastric hirtidine decarboxylase. The results suggest that the kidney is important for metabolism and excretion not only of gastrin but of humoral antagonists of gastrin-induced acid secretion as well.

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References

  1. W. D. Davidson, T. C. Moore, W. Shippey andA. J. Conovaloff, Gastroenterology66, 522 (1974).

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  2. H. A. El Munshid, G. Liedberg, J. F. Rehfeld, F. Sundler, L.-I. Larsson andR. Håkanson, Scand. J. Gastroent., in press (1975).

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Håkanson, R., El Munshid, H.A., Liedberg, G. et al. Effect of bilateral nephrectomy on serum gastrin concentration, gastric histamine content, histidine decarboxylase activity and acid secretion in the rat. Agents and Actions 5, 456 (1975). https://doi.org/10.1007/BF01972668

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  • DOI: https://doi.org/10.1007/BF01972668

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