Advertisement

Agents and Actions

, Volume 5, Issue 5, pp 456–456 | Cite as

Effect of bilateral nephrectomy on serum gastrin concentration, gastric histamine content, histidine decarboxylase activity and acid secretion in the rat

  • R. Håkanson
  • H. A. El Munshid
  • G. Liedberg
  • J. F. Rehfeld
  • F. Sundler
  • L. -I. Larsson
Models in Toxicology Abstracts of other papers given at the `4th Annual Meeting of the European Branch of the Histamine Club', Florence 5–6 June 1975
  • 12 Downloads

Conclusion

In the nephrectomized rat gastrin (and pentagastrin) does not evoke acid secretion but retains its ability to activate gastric hirtidine decarboxylase. The results suggest that the kidney is important for metabolism and excretion not only of gastrin but of humoral antagonists of gastrin-induced acid secretion as well.

Keywords

Histamine Histidine Acid Secretion Serum Gastrin Pentagastrin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. [1]
    W. D. Davidson, T. C. Moore, W. Shippey andA. J. Conovaloff, Gastroenterology66, 522 (1974).PubMedGoogle Scholar
  2. [2]
    H. A. El Munshid, G. Liedberg, J. F. Rehfeld, F. Sundler, L.-I. Larsson andR. Håkanson, Scand. J. Gastroent., in press (1975).Google Scholar

Copyright information

© Birkhäuser Verlag 1975

Authors and Affiliations

  • R. Håkanson
    • 1
  • H. A. El Munshid
    • 1
  • G. Liedberg
    • 1
  • J. F. Rehfeld
    • 1
  • F. Sundler
    • 1
  • L. -I. Larsson
    • 1
  1. 1.Department of PharmacologyUniversity of LundLundSweden

Personalised recommendations