Advertisement

Agents and Actions

, Volume 5, Issue 5, pp 402–416 | Cite as

Histamine release in man

  • W. Lorenz
Histamine and Kinins Review

Conclusions

  1. (1)

    Histamine release in man could be demonstrated using the fluorometric histamine assay in plasma as a reliable test.

     
  2. (2)

    Histamine release in animals may be relevant in some cases for human subjects, as shown for anaesthetic drugs and plasma substitutes on gelatin basis. In other cases histamine release in animals may not be relevant for man as demonstrated for dextran.

     
  3. (3)

    Even if a small histamine release could be detected in human subjects as in the case of dextran this must not implicate that also in severe anaphylactoid incidents histamine release is the cause of these events.

     
  4. (4)

    Plasma histamine determinations led to a much better understanding of histamine-induced reactions in human subjects than other techniques and — which is the most important advantage — increase the possibility to differentiate between histamine-induced reactions and anaphylactoid reactions caused by other mediators. The suggestion in former time that histamine might be involved in all types of ‘allergic’ reactions induced a histamine philosophy. Differentiation, however, gives histamine its place at least in human pathophysiology.

     

Keywords

Histamine Gelatin Human Subject Dextran Histamine Release 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. [1]
    M. Zindler, H. Yamamura andW. Wirth,Intravenöse Narkose mit Propanidid, Anaesthesiologie und Wiederbelebung, vol.74, 1 (Springer, Berlin, Heidelberg, New York 1973), p. 325 ff.Google Scholar
  2. [2]
    W. Lorenz, A. Doenicke, S. Halbach, I. Krumey andE. Werle,histaminfreisetzung und Magensaftsekretion bei Narkosen mit Propanidid (Epontol ®), Klin. Wschr.47, 154–157 (1969).CrossRefPubMedGoogle Scholar
  3. [3]
    W. Lorenz, A. Doenicke, R. Meyer, H.J. Reimann, J. Kusche, H. Barth, H. Geesing, M. Hutzel andB. Weissenbacher,An Improved Method for the Determination of Histamine Release in Man: Its Application in Studies with Propanidid and Thiopentone, Eur. J. Pharmac.19, 180–190 (1972).CrossRefGoogle Scholar
  4. [4]
    R. Richterich,Klinische Chemie — Theorie und Praxis (Akademische Verlagsgesellschaft, Frankfurt 1965), p. 34.Google Scholar
  5. [5]
    W. Lorenz, H. Barth, H.E. Karges, A. Schmal, P. Dormann andI. Niemeyer,Problems in the Assay of Histamine Release by Gelatin: o-Phthaldialdehyde-Induced Fluorescence, Inhibition of Histamine Methyltransferase and H 1-Receptor Antagonism by Haemaccel, Agents and Actions4, 324–335 (1974).PubMedGoogle Scholar
  6. [6]
    W. Lorenz, H.J. Reimann, H. Barth, J. Kusche, R. Meyer, A. Doenicke andM. Hutzel,A Sensitive and Specific Method for the Determination of Histamine in Human Whole Blood and Plasma, Hoppe-Seyler's Z. Physiol. Chem.353, 911–920 (1972).PubMedGoogle Scholar
  7. [7]
    W. Lorenz, H. Barth, M. Thermann, A. Schmal, P. Dormann andI. Niemeyer,Fluorometric Histamine Determination in Canine Plasma at Normal Conditions, Following Application of Exogenous Histamine and during Histamine Release by Haemaccel ®, Hoppe-Seyler's Z. Physiol. Chem.335, 1097–1111 (1974).Google Scholar
  8. [8]
    W. Lorenz, L. Benesch, H. Barth, E. Matejka, R. Meyer, J. Kusche, M. Hutzel andE. Werle,Fluorometric Assay of Histamine in Tissues and Body Fluids: Choice of the Purification Procedure and Identification in the Nanogram Range, Z. Analyt. Chem.252, 94–98 (1970).CrossRefGoogle Scholar
  9. [9]
    W. Lorenz, H. Troidl, S. Schulz, H. Becker, P. Dormann, A. Schmal, R. Meyer, J. Kusche, H. Barth, H. Rohde,Stimulus-Secretion Coupling in the Human and Canine Stomach: Role of Histamine, International conference on stimulus-secretion coupling in the gastrointestinal tract, Titisee, Mai 1975 (in press).Google Scholar
  10. [10]
    R. Håkanson, A.L. Rönnberg andK. Sjölund,Fluorometric Determination of Histamine with OPT: Optimum Reaction Conditions and Tests of Identity, Analyt. Biochem.47, 356–370 (1972).CrossRefPubMedGoogle Scholar
  11. [11]
    J.A.H. Gooszen,The Use of Control Charts in the Clinical Laboratory, Clin. Chem. Acta5, 431–436 (1960).CrossRefGoogle Scholar
  12. [12]
    H. U. Bergmeyer,Methoden der enzymatischen Analyse, 2nd ed. (Verlag Chemie, Weinheim/Bergstrasse 1970).Google Scholar
  13. [13]
    W. Lorenz, A. Doenicke, R. Meyer, H.J. Reimann, J. Kusche, H. Barth, H. Geesing, M. Hutzel andB. Weissenbacher,Histamine Release in Man by Propanidid and Thiopentone: Pharmacological Effects and Clinical Consequences, Br. J. Anaesth.44, 355–369 (1972).PubMedGoogle Scholar
  14. [14]
    A. Doenicke, W. Lorenz, R. Beigl, H. Bezecny, G. Uhlig, L. Kalmar, B. Praetorius andG. Mann,Histamine Release after Intravenous Application of Short-Acting Hypnotics: A Comparison of Etomidate, Althesin CT 1341 and Propanidid, Br. J. Anaesth.45, 1097–1104 (1973).PubMedGoogle Scholar
  15. [15]
    W. Lorenz, A. Doenicke, K. Messmer, H.-J. Reimann, M. Thermann, W. Lahn, J. Beer, A. Schmal, P. Dormann, P. Regenfuss andH. Hamelmann,Histamine Release in Human Subjects by Modified Gelatin (Haemaccel ®)and Dextran: Explanation for Anaphylactoid Reactions Observed under Clinical Conditions?, Br. J. Anaesth. (in press).Google Scholar
  16. [16]
    W. Lorenz, H. Barth, J. Kusche, H.-J. Reimann, A. Schmal, E. Matejka, Ch. Mathias, M. Hutzel andE. Werle,Histamine in the Pig: Determination, Distribution, Release and Pharmacological Actions, Eur. J. Pharmac.14, 155–175 (1971).CrossRefGoogle Scholar
  17. [17]
    K. Messmer, W. Lorenz, L. Sunder-Plassmann, W. Klövekorn andM. Hutzel,Histamine Release as Cause of Acute Hypotension Following Rapid Colloid Infusion, Naunyn-Schmiedebergs Arch. Pharmak.267, 433–445 (1970).CrossRefGoogle Scholar
  18. [18]
    W. Lorenz, M. Thermann, H. Hamelmann, A. Schmal, D. Maroske, H.J. Reimann, J. Kusche, F. Schingale, P. Dormann andP. Keck,Influence of H 1-and H 2-Receptor Antagonists on the Effects of Histamine in the Circulatory System and on Plasma Histamine Levels, Int. Symposium on Histamine H2-receptor antagonists (Ed. Clive J. Wood and M.A. Simkins, Deltakos [UK] Ltd. London, W1 (1973), p. 151–168.Google Scholar
  19. [19]
    H.T. Graham, J.A.D. Scarpellini, B.P. Hubka andD.H. Lowry,Measurement and Normal Range of Free Histamine in Human Blood Plasma, Biochem. Pharmac.17, 2271–2280 (1963).CrossRefGoogle Scholar
  20. [20]
    R.L. Miller, C. McCord, M. Sanda, H.R. Bourne andK.L. Melmon,Application of the Enzymatic Double Isotope Dilution Assay for the Study of Histamine in Plasma, J. Pharmac. exp. Ther.175, 228–234 (1970).Google Scholar
  21. [21]
    W. Lorenz, W. Seidel, A. Doenicke, R. Tauber, H.-J. Reimann, R. Uhlig, G. Mann, P. Dormann, A. Schmal, G. Häfner andH. Hamelman,Elevated Plasma Histamine Concentrations in Surgery: Causes and Clinical Significance, Klin. Wschr.52, 419–425 (1974).CrossRefPubMedGoogle Scholar
  22. [22]
    W. Lorenz, W. Thermann, K. Messmer, A. Schmal, P. Dormann, J. Kusche, H. Barth, R. Tauber, M. Hutzel, G. Mann andR. Uhlig,Evaluation of Histamine Elimination Curves in Plasma and Whole Blood of Several Circulatory Regions: A Method for Studying Kinetics of Histamine Release in the Whole Animal, Agents and Actions4, 336–356 (1974).PubMedGoogle Scholar
  23. [23]
    W. Lorenz, A. Doenicke, M. Freundt, A. Schmal, P. Dormann, B. Praetorius andM. Schürk-Bolich,Plasmahistaminspiegel beim Menschen nach rascher Infusion von Hydroxyäthylstärke: Ein Beitrag zur Frage allergischer oder anaphylaktoider Reaktionen nach Gabe eines neuen Plasmasubstitutes, Anästhesist24, 228–230 (1975).Google Scholar
  24. [24]
    A. Doenicke andW. Lorenz,Nachweis von Histaminfreisetzung bei hypotensiven Reaktionen nach Propanidid und ihrer Therapie mit Corticosteroiden, Anäthesie u. Wiederbelebung74, 189–199 (1973).Google Scholar
  25. [25]
    R. Tauber, D. Maroske, H. Schult, P. Dormann, A. Schmal, G. Häfner andW. Lorenz,Speicherung von Histamin in Blut nach Freisetzung aus Leber und Antrum durch Trypsin: protektiver Mechanismus oder Faktor in der Genese des pankreogenen Schocks? Langenbecks Arch. Chir. Suppl. Chir. Forum (1975), p. 213.Google Scholar
  26. [26]
    W. Lorenz, A. Doenicke, G. Feifel, K. Messmer, R. Meyer, L. Benesch, H. Barth, J. Kusche, M. Hutzel undE. Werle,Histamine Release in Man by Propanidid (Epontol ®),Gelatin (Haemaccel ®)Histalog, Pentagastrin and Insulin, Naunyn-Schmiedebergs Arch. Pharmak.266, 396 (1970).CrossRefGoogle Scholar
  27. [27]
    A. Doenicke andW. Lorenz,Histaminfreisetzung und anaphylaktische Reaktionen bei Narkosen. Biochemische und klinische Aspekte, Anästhesist19, 413–417 (1970).Google Scholar
  28. [28]
    W. Lorenz, A. Doenicke, R. Meyer, H.J. Reimann andE. Werle,Histamine Release in Man as Cause of Hypotensive Reactions after Anaesthesia with Propanidid, Naunyn-Schmiedebergs Arch. Pharmak., suppl. to vol. 270, R90 (1971).CrossRefGoogle Scholar
  29. [29]
    W. Lorenz andA. Doenicke,Biochemie und Pharmakologie der Histaminfreisetzung durch intravenöse Narkosemittel und Muskelrelaxantien, Anästhesie u. Wiederbelebung74, 179–188 (1973).Google Scholar
  30. [30]
    C. Meyer-Burgdorff, G. Seidel andF.J. Schlüter,Freisetzung von Histamin und Serotonin bei extrakorporaler Zirkulation, Anästhesist22, 212–216 (1973).Google Scholar
  31. [31]
    G. Seidel andC. Meyer-Burgdorff,Freisetzung von Histamin durch Propanidid-Toxizität von Epontol nach Kontakt mit Kunststoff, Anästhesie u. Wiederbelebung74, 224–227 (1973).Google Scholar
  32. [32]
    C. Meyer-Burgdorff, G. Seidel andI. Wolf,Histaminfreisetzung durch Narkosemittel, Anästhesist (submitted for publication).Google Scholar
  33. [33]
    W. Lorenz, R. Meyer, A. Doenicke, A. Schmal, H.J. Reimann, M. Hutzel andE. Werle,On the Species Specifity of the Histamine Release from Mast Cell Stores by Cremophor-El, Naunyn-Schmiedebergs Arch. Pharmak.269, 417 (1971).Google Scholar
  34. [34]
    W. Lorenz, H.J. Reimann andA. Schmal,The Site of Histamine Release in Dog by Cremophor El, Abst. 5th Int. Congr. Pharmac., San Francisco (1972), p. 142.Google Scholar
  35. [35]
    W. Lorenz, H.J. Reimann, A. Schmal, R. Tauber, andR. Uhlig,Histamine Release from Typical and Atypical Mast Cell Stores by Cremophor El, Naunyn-Schmiedebergs Arch. Pharmak., suppl. to274, R75 (1972).Google Scholar
  36. [36]
    M. Werner andE. Wolff,Klinisch-experimentelle Untersuchungen zur Frage der Propanidid-Allergie, in:Intravenöse Narkose mit Propanidid (Eds. M. Zindler, H. Yamamura and W. Wirth, Springer, Berlin, Heidelberg, New York 1973), Anästhesie u. Wiederbelebung74, 217–223.Google Scholar
  37. [37]
    F. Hahn andA. Wellmann,Experimentelle Untersuchungen über Histaminfreisetzung durch künstliche Blutersatzmittel, Klin. Wschr.30, 998–1000 (1952).CrossRefPubMedGoogle Scholar
  38. [38]
    K. Messmer, W. Lorenz, H. Haendle, W.P. Klövekorn andM. Hutzel,Acute Hypotension and Histamine Liberation Following Rapid Infusion of Plasma Substitutes in Dogs, Eur. Surg. Res.1, 188 (1969).Google Scholar
  39. [39]
    W. Lorenz, A. Doenicke, K. Messmer andH.J. Reimann,Histamine Release in Man and Dog by Plasma Substitutes, Acta Pharmac. Toxic.29, suppl. 4, 31 (1971).Google Scholar
  40. [40]
    W. Lorenz, A. Doenicke, H.-J. Reimann, M. Thermann, R. Tauber, A. Schmal, P. Dormann, H. Hensel, H. Hamelmann andE. Werle,Plasma Histamine Determination in Man and Dog Following the Infusion of Plasma Substitutes: Models for Histamine Release under Pathophysiological Conditions, Agents and Actions3, 183–184 (1973).PubMedGoogle Scholar
  41. [41]
    W. Lorenz, H. Barth, A. Schmal, I. Niemeyer andP. Dormann,o-Phthaldialdehyde Reactive Substances in Dog's Plasma and Gelatin (Haemaccel) Complicating the Determination of Histamine, Agents and Actions4, 206–208 (1974).PubMedGoogle Scholar
  42. [42]
    M. Thermann, A. Doenicke, K. Messmer, H. Hamelmann, H.J. Reimann andW. Lorenz,Histaminfreisetzung beim Menschen durch Plasma-substitute auf Gelatine- und Dextranbasis: Ursache der anaphylaktoiden Reaktionen in der Klinik?, Langenbecks Arch. Chir. Suppl. Chir. Forum (1975), p. 435.Google Scholar
  43. [43]
    M. Wiedersheim,An Investigation of Oxyethylstarch as a New Plasma Volume Expander in Animals, Arch. int. Pharmacodyn.111, 353 (1957).PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1975

Authors and Affiliations

  • W. Lorenz
    • 1
  1. 1.Division of Experimental Surgery and Pathological Biochemistry at the Surgical ClinicUniversity of Marburg a.d. LahnFederal Republic of Germany

Personalised recommendations