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Comparative in vitro activity of the new glycopeptide SK&F 104662 against problematic gram-positive bacteria

  • New Antimicrobial Agents
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Abstract

The in vitro activity of the new glycopeptide antibotic SK&F 104662 against problematic gram-positive microorganisms was determined using the agar dilution technique. For comparison, ampicillin, oxacillin, vancomycin, erythromycin and gentamicin were tested. SK&F 104662 was found to have high activity againstStaphylococcus aureus, coagulase-negative staphylococci (both methicillin sensitive and resistant strains),Enterococcus faecalis, Enterococcus faecium, Listeria monocytogenes, Corynebacterium jeikeium andCorynebacterium group D2. All of 254 isolates, except one vancomycin-resistant strain ofEnterococcus faecium, were inhibited by 2 mg/l of SK&F 104662; this compound may thus be potentially useful in the treatment of infections with the above-mentioned gram-positive pathogens.

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Authors and Affiliations

  1. Department of Microbiology, Fundación Jiménez Diaz, Universidad Autónoma de Madrid, Avda. Reyes Católicos 2, 28040, Madrid, Spain

    F. Soriano, J. Zapardiel & R. Fernández-Roblas

Authors
  1. F. Soriano
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  2. J. Zapardiel
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  3. R. Fernández-Roblas
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Soriano, F., Zapardiel, J. & Fernández-Roblas, R. Comparative in vitro activity of the new glycopeptide SK&F 104662 against problematic gram-positive bacteria. Eur. J. Clin. Microbiol. Infect. Dis. 10, 782–784 (1991). https://doi.org/10.1007/BF01972511

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  • DOI: https://doi.org/10.1007/BF01972511

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