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Surface activation of factor XII (Hageman factor) — Critical role of high molecular weight kininogen and another potentiator

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Abstract

When factor XII was adsorbed to kaolin it slowly became activated and converted prekallikrein to kallikrein. In the presence of HMW-kininogen the rate of activation of factor XII and consequently that of prekallikrein was markedly enhanced. The enhancing effect of HMW-kininogen was a dose-dependent phenomenon. In order to enhance the activation of factor XII on a surface the HMW-kininogen molecule had to be intact. Cleavage of HMW-kininogen by kallikrein decreased the enhancing effect of HMW-kininogen, there being an inverse relation between the bradykinin-generated and the capacity to enhance factor XII activation. Another ‘potentiator’ of factor XII activation was isolated from proteins adsorbed to aluminum hydroxide. This potentiator further increased the activation of factor XII, also in a dose-dependent fashion. It was postulated that factor XII is slowly converted into its active form by exposure to negatively charged surfaces; that this process is enhanced by kallikrein and further accelerated by HMW-kininogen and the ‘potentiator’; and that these enhancing substances probably act by opening active sites on the factor XII molecule.

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Authors and Affiliations

  1. Division of Experimental Pathology, Department of Pathology, University of Toronto, Medical Sciences Building, M5S 1A8, Toronto, Ontario, Canada

    J. Y. C. Chan, C. E. Burrowes & H. Z. Movat (Holder of an Associateship of the Medical Research Council of Canada)

  2. Institute of Immunology, University of Toronto, Medical Sciences Building, M5S 1A8, Toronto, Ontario, Canada

    J. Y. C. Chan, C. E. Burrowes & H. Z. Movat (Holder of an Associateship of the Medical Research Council of Canada)

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  1. J. Y. C. Chan
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  2. C. E. Burrowes
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  3. H. Z. Movat
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Supported by a grant from the Ontario Heart Foundation.

Supported by the Medical Research Council of Canada.

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Chan, J.Y.C., Burrowes, C.E. & Movat, H.Z. Surface activation of factor XII (Hageman factor) — Critical role of high molecular weight kininogen and another potentiator. Agents and Actions 8, 65–72 (1978). https://doi.org/10.1007/BF01972404

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