Agents and Actions

, Volume 15, Issue 3–4, pp 229–234 | Cite as

Plasma histamine and hemodynamic responses following administration of nalbuphine and morphine

  • S. M. Muldoon
  • M. A. Donlon
  • R. Todd
  • E. A. Helgeson
  • W. Freas
Histamine and Kinins

Abstract

A comparative study of plasma histamine levels following administration or morphine and nalbuphine in pentobarbital anesthetized dogs was performed. Two concentrations, 3 mg/kg and 0.3 mg/kg of these drugs were investigated. High dose morphine caused an immediate marked increase in plasma histamine from 5.0±0.4 to 340±72 ng/ml. Simultaneous with this increase in plasma histamine was a marked decrease in mean arterial blood pressure within the first minute. In contrast significant alterations in plasma histamine levels were not observed with high or low doses of nalbuphine. A low dose of morphine (0.3 mg/kg) did not increase plasma histamine levels. Heart rate was not changed by any drug treatment. The use of compound 48/80 a specific mast cell degranulating agent allowed for the identification of a specific pool of mast cells capable of responding to morphine.In vitro exposure of purified dog leukocytes to high doses of morphine did not result in histamine release. These results indicate that nalbuphine does not increase plasma histamine, while morphine does, and that the source of the increase in plasma histamine is from tissue mast cells.

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References

  1. [1]
    E. Lowenstein, P. Hallowell, F.H. LeVine, W.M. Daggett, W.G. Austen andM.B. Laver,Cardiovascular response to large doses of intravenous morphine in man, New Engl. J. Med.281, 1389–1393 (1969).Google Scholar
  2. [2]
    T.H. Stanley, N.H. Gray, W. Stanford andR. Armstrong,The effect of high dose morphine on fluid and blood requirements in open heart operations, Anesthesiology38, 536–541 (1973).Google Scholar
  3. [3]
    K.C. Wong, W.E. Martin, T.F. Horbein, F.G. Freund andJ. Everett,The cardiovascular effect of morphine with oxygen and with nitrous oxide in man, Anesthesiology38, 541–549 (1973).Google Scholar
  4. [4]
    T.H. Stanley andL.R. Webster,Anesthetic requirement and cardiovascular effect of fentanyl oxygen and fentanyl diazepam oxygen anesthesia in man, Anesth. Analg. (Cleve)57, 411–416 (1978).Google Scholar
  5. [5]
    J.E. Eckenhoff andS.R. Oech,The Effects of narcotics and antagonist upon respiration and circulation in man, Clin. Parmac. Ther.1, 483–524 (1960).Google Scholar
  6. [6]
    C.E. Rosow, J. Moss, D.M. Philbin andJ.J. Savarese,Histamine release during morphine and fentanyl anesthesia, Anesthesiology56, 93–96 (1982).Google Scholar
  7. [7]
    C.L. Lake, E.N. Duckworth, C.A. DiFazio, C.G. Durbin andM.R. Magruder,Cardiovascular effects of nalbuphine in patients with coronary or valvular heart disease, Anesthesiology37, 498–503 (1982).Google Scholar
  8. [8]
    R.P. Siraganian,An automated continuous-flow system for the extraction and fluorometric analysis of histamine, Analyt. Biochem.57, 383–394 (1974).Google Scholar
  9. [9]
    R.P. Siraganian, Histamine release and assay methods for the study of human allergy. InManual of Clinical Immunology, pp. 603–625. (Eds.N.R. Rose andH. Friedman) American Society for Microbiology, Washington, DC 1976.Google Scholar
  10. [10]
    C.D. May, M. Lyman, R. Alberto andF. Cheng,Procedures for immunochemical study of histamine release from leukocytes with small blood volume, J. Allergy46, 12–20 (1970).Google Scholar
  11. [11]
    J.E. Schurig, R.L. Cavanagh andJ.P. Buyniski,Effect of butorphanol and morphine on pulmonary mechanics, arterial blood pressure and venous plasma histamine in the anesthetized dog, Archs. int. Pharmacodyn. Thér.233, 296–304 (1978).Google Scholar
  12. [12]
    D.M. Philbin, J. Moss, C.W. Akins, C.E. Rosow, K. Kono, R.C. Schneider, T.R. VerLee andJ.J. Savarese,The use of H 1 and H 2 histamine antagonists with morphine anesthesia: a double-bind study, Anesthesiology55, 292–296 (1981).Google Scholar
  13. [13]
    W. Lorenz, H. Barth, M. Thermann, A. Schmal, P. Dormann andI. Niemeyer,Fluorometric histamine determination in canine plasma under normal conditions, following application of exogenous histamine, and during histamine release by Haemaccel, Hoppe-Seyler's Z. Physiol. Chem.355, 1097–1111 (1974).Google Scholar
  14. [14]
    W. Lorenz, M. Thermann, K. Messmer, A. Schmal, P. Dormann, J. Kusche, H. Barth, R. Tauber, M. Hutzel, G. Mann andR. Uhlig,Evaluation of histamine elimination curves in plasma and whole blood of several circulatory regions: a method for studying kinetics of histamine release in the whole animal, Agents and Actions4, 336–356 (1974).Google Scholar
  15. [15]
    D.A.A. Owen, C.A. Harvey andM.J. Boyce,Effects of histamine on the circulatory system, Klin. Wschr.60, 972–977 (1982).Google Scholar
  16. [16]
    J.P. Trzeciakowski andR. Levi,Cardiac histamine: a mediator in search of a function, Trends in Pharmacol. Sciences2, 14–17 (1981).Google Scholar
  17. [17]
    J.W. Constantine andW.S. Lebel,Histamine release in dogs by Emulphor EL620, Experientia35, 338–339 (1978).Google Scholar
  18. [18]
    W. Kazimierczak andB. Diamont,Mechanisms of histamine release in anaphylactic and anaphylactoid reactions, Prog. Allergy24, 295–365 (1974).Google Scholar
  19. [15]
    P.B. Dews, A.L. Wnuck, R.V. Fanelli, A.E. Light, J.A. Tornaber, S. Norton, C.H. Ellis andE.J. DeBeer,The pharmacology of 48/80 a long acting vasodepressor drug, J. Pharmac. exp. Ther.107, 1–11 (1953).Google Scholar
  20. [20]
    A.N. Smith,Release of histamine by the histamine liberator compound 48/80 in cats, J. Physiol., Lond.121, 517–538 (1953).Google Scholar
  21. [21]
    W. Felberg andJ. Talesnik,Reduction of tissue histamine by compound 48/80, J. Physiol. Lond. 20, 550–568 (1953).Google Scholar
  22. [22]
    W. Lorenz, J.V. Parkin, H. Rohde, H. Barth, H. Troidl, K. Thon, E. Hinterlang, D. Weber, R. Albrecht andH. Roher, Histamine in gastric secretory disorders: the relevance of the mucosal histamine content and the origin of histamine in gastric aspirate. InGastric Secretion, Basic and Clinical Aspects (EdsS.J. Konturek andW. Domschke). Georg Thieme Verlag, Stuttgart-New York, Thieme-Stratton Inc., New York 1981.Google Scholar
  23. [23]
    W. Lorenz, K. Mohri, H.-J. Reimann, H. Troidl, H. Rohde andH. Barth, Intramucosal mechanisms: relevance of the mast cell concept, Inter Congress Series 537,Advances in Ulcer Disease, pp. 177–191. Excerpta Medica, Amsterdam-Oxford-Princeton 1981.Google Scholar
  24. [24]
    L. Enerback,Mast cells in rat gastrointestinal mucosa. III. Reactivity towards compound 48/80, Acta Path. Microbiol. Scand.66, 316 (1966).Google Scholar
  25. [25]
    F.L. Pearce,Mast cell heterogeneity, Trends in Pharmacol. Sciences4, 165–166 (1983).Google Scholar
  26. [26]
    W.D.M. Paton,The release of histamine, Prog. Allergy5, 79–148 (1958).Google Scholar
  27. [27]
    W. Lorenz andA. Doenicke,Histamine release in clinical conditions, The Mount Sinai, J. Med.45, 357–386 (1978).Google Scholar
  28. [28]
    R.R. Miller,Evaluation of nalbuphine hydrochloride, Am. J. Hosp. Pharm.37, 942–949 (1980).Google Scholar
  29. [29]
    W.T. Beaver andG.A. Feise,A comparison of the analgesic effect of intramuscular nalbuphine and morphine in patients with postoperative pain, J. Pharmac. Exp. Ther.204, 487–496 (1978).Google Scholar
  30. [30]
    A Romagnoli andA.S. Keats,Ceiling effect for respiratory depression by nalbuphine, Clin. Pharmac. Ther.27, 478–485 (1980).Google Scholar
  31. [31]
    G. Lee, R.I. Low, E.A. Amsterdam, A.N. DeMaria, P.W. Huber andD.T. Mason,Hemodynamic effects of morphine and nalbuphine in acute myocardial infaction, Clin. Pharmac. Ther.29, 576–581 (1981).Google Scholar
  32. [32]
    S.M. Muldoon, J. Otto, W. Freas andR.L. Watson,The effect of morphine, nalbuphine and butorphanol on adrenergic function in canine saphenous veins, Anesth. Analg.62, 21–28 (1983).Google Scholar

Copyright information

© Birkhäuser Verlag 1984

Authors and Affiliations

  • S. M. Muldoon
    • 1
  • M. A. Donlon
    • 2
  • R. Todd
    • 1
  • E. A. Helgeson
    • 2
  • W. Freas
    • 1
  1. 1.Department of AnesthesiologyUniformed Services University of the Health SciencesBethesdaUSA
  2. 2.Department of BiochemistryArmed Forces Radiobiology Research InstituteBethesdaUSA

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