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Effects of polycyclic hydrocarbons on the induction of chromosomal aberrations in absence of an exogenous metabolic activation system in cultured hamster cells

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  • Pharmacologica
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Summary

The effect of carcinogenic polycyclic hydrocarbons on the chromosomes of cultured Chinese hamster cells was investigated. Contrary to earlier reports it was observed that benz(a)anthracene, benzo(a)pyrene, 7, 12-dimethylbenz(a)anthracene and 3-methylcholanthrene were effective in causing chromosomal aberrations without any exogenous metabolic activation. Duration of incubation with these agents may be the cause of difference in results. Importance of prolonged treatment period is discussed.

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Authors and Affiliations

  1. Department of Biology, Kentucky State University, 40601, Frankfort, Kentucky, USA

    T. S. Kochhar

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  1. T. S. Kochhar
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Additional information

This study was supported by NIH-Minority Biomedical Support Program. Grant No. 5 RRO8124-05. Technical assistance of NIH-MBS students Rosetta Newsome and Samuel Loften is gratefully acknowledged.

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Kochhar, T.S. Effects of polycyclic hydrocarbons on the induction of chromosomal aberrations in absence of an exogenous metabolic activation system in cultured hamster cells. Experientia 38, 845–846 (1982). https://doi.org/10.1007/BF01972308

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  • DOI: https://doi.org/10.1007/BF01972308

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