Skip to main content
SpringerLink
Log in

Digoxin distribution between plasma and myocardium in hypoxic and non-hypoxic dogs

  • Specialia
  • Pharmacologica
  • Published:
Experientia Aims and scope Submit manuscript

Summary

The relationship between plasma and myocardial digoxin concentrations was investigated in hypoxic and nonhypoxic dogs. The results indicate that hypoxic dogs have lower plasma levels, higher myocardial levels, and an altered myocardial distribution when compared to non-hypoxic dogs.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. J. E. Doherty, W. H. Perkins and W. J. Flanigan, Ann. intern. Med.66, 116 (1967).

    Article  CAS  PubMed  Google Scholar 

  2. D. C. Evered and C. Chapman, Br. Heart J.33, 540 (1971).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. A. A. Bertler, A. Gustafson, P. Ohlin, M. Monti and A. Redford, Symposium on Digitalis, p. 300. Gyldendal Norsk Forlag, Oslo 1973.

    Google Scholar 

  4. R. N. Deutscher, D. C. Harrison and R. H. Goldman, Am. J. Cardiol.29, 47 (1971).

    Article  Google Scholar 

  5. M. A. Davis, D. Maclean and P. R. Mavoko, Br. J. clin. Pharmac.7, 430 (1978).

    Google Scholar 

  6. J. K. Aronson and D. G. Grahame-Smith, Br. J. clin. Pharmac.4, 223 (1976).

    Article  Google Scholar 

  7. D. J. Coltart, H. G. Gohlner, M. Billingham, R. H. Goldman, E. B. Stinson and S. M. Kalman, Post-grad. med. J.51, 330 (1975).

    Article  CAS  Google Scholar 

  8. J. P. Payne and C. M. Conway, Post-grad. med. J.42, 341 (1966).

    Article  Google Scholar 

  9. R. D. Eastham, in: Biochemical values in clinical medicine, 6th edn, p. 153. Wright & Sons Ltd, Bristol 1978.

    Google Scholar 

  10. P. B. Beeson and W. McDermott, eds, in: Textbook of medicine, 14th edn, p. 892. W. B. Saunders, Philadelphia 1975.

    Google Scholar 

  11. N. P. Kubasik, J. Lefkowitz-Hall, S. S. Barold, M. T. Volosin and H. E. Sine, Chest70, 217 (1976).

    Article  CAS  PubMed  Google Scholar 

  12. Wellcome Reagents Limited. Manufacturers literature Lanoxitest Digoxin Radio-immunoassay Kit, RD35.

  13. D. W. G. Harron, P. Collier and D. Temple, Unpublished observations.

Download references

Author information

Authors and Affiliations

  1. Department of Therapeutics and Pharmacology, The Queen's University of Belfast, BT9 7BL, Belfast, Northern Ireland

    D. W. G. Harron, J. G. Swanton, P. S. Collier & A. B. Cullen

  2. Department of Pharmacy, The Queen's University of Belfast, BT9 7BL, Belfast, Northern Ireland

    D. W. G. Harron, J. G. Swanton, P. S. Collier & A. B. Cullen

Authors
  1. D. W. G. Harron
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. G. Swanton
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. S. Collier
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. B. Cullen
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Harron, D.W.G., Swanton, J.G., Collier, P.S. et al. Digoxin distribution between plasma and myocardium in hypoxic and non-hypoxic dogs. Experientia 38, 839–841 (1982). https://doi.org/10.1007/BF01972304

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01972304

Keywords

Search

Navigation