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Mechanisms of coronary vasoconstriction induced by Na arachidonate in experimentally diabetic dogs

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Summary

Na arachidonate (NaA) enhanced the resting basal tone of isolated coronary arteries from diabetic dogs and depressed it in coronary arteries from normal controls. Inhibitors of thromboxane A2 biosynthesis and of lipoxygenases abolished the vasoconstrictor effect of NaA on diabetic arteries, whereas inhibitors of cyclooxygenase activity and PGI2 biosynthesis blocked the vasodilating action of NaA on normal arteries.

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Authors and Affiliations

  1. Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Serrano 665/69, 1414, Buenos Aires, Argentina

    L. Sterin-Borda, E. Borda, E. J. del Castillo, M. F. Gimeno & A. L. Gimeno

Authors
  1. L. Sterin-Borda
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  2. E. Borda
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  3. E. J. del Castillo
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  4. M. F. Gimeno
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  5. A. L. Gimeno
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Additional information

This work has been supported by grant 6638 from CONICET (Argentina).

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Sterin-Borda, L., Borda, E., del Castillo, E.J. et al. Mechanisms of coronary vasoconstriction induced by Na arachidonate in experimentally diabetic dogs. Experientia 38, 835–837 (1982). https://doi.org/10.1007/BF01972301

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  • DOI: https://doi.org/10.1007/BF01972301

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