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Endotoxin inhibits the fluoride-stimulated adenylate cyclase activity of rat liver plasma membranes enriched with bile canaliculi

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  • Pharmacologica
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Summary

Escherichia coli endotoxin inhibited the fluoride-stimulated adenylate cyclase activity of liver plasma membranes enriched with bile canaliculi. Inhibition was of a mixed competitive and uncompetitive type. This effect, which may result from changes of membrane organization, may have relevance in the understanding of endotoxin-cell membrane interactions.

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Authors and Affiliations

  1. Institute of Chemical Biology, University of Naples, Via Costantinopoli 16, I-80135, Naples, Italy

    R. Utili, A. Di Donato, G. Draetta, G. Paolisso, C. O. Abernathy & G. Illiano

  2. Clinic of Infectious Diseases, University of Naples, 1st Medical Schooo, Via Cotugno 1, I-80135, Naples, Italy

    R. Utili, A. Di Donato, G. Draetta, G. Paolisso, C. O. Abernathy & G. Illiano

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  1. R. Utili
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  2. A. Di Donato
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  3. G. Draetta
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  4. G. Paolisso
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  5. C. O. Abernathy
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  6. G. Illiano
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Utili, R., Di Donato, A., Draetta, G. et al. Endotoxin inhibits the fluoride-stimulated adenylate cyclase activity of rat liver plasma membranes enriched with bile canaliculi. Experientia 38, 831–833 (1982). https://doi.org/10.1007/BF01972299

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  • DOI: https://doi.org/10.1007/BF01972299

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