Abstract
Collagen is abundantly synthesized in granulation tissues and reaches a concentration higher than in normal neighbouring tissues. Such newly formed collagen is characterized by an abnormally low solubility and an easy degradation by collagenases and collagenolytic cathepsins. The activities of these two types of enzymes are high (especially collagenases) in tissues of acute inflammations when the granuloma is resorbing. These activities are lower in subacute inflammation and the collagen content of the persistent granuloma remains high.
The collagen synthesized in granulation tissues is cross linked by hydroxylysino-5-keto-norleucine, the stable cross-link of collagen in embryonic skin. It is progressively replaced by the two aldimine cross links of normal adult skin when the granuloma is resorbed (acute inflammations induced in rats; human normal scars). The cross link of embryonic skin, on the contrary, is permanently present in collagen of tissues of subacute, chronic inflammations (sponge implants in rats, human hypertrophic scars and keloids).
Studies of the structure of α-chains revealed that type III collagen (embryonic collagen) is present in granulation tissues.
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A.J. Bailey, S. Bazin and A. Delaunay,Changes in the nature of the collagen during development and resorption of granulation tissue, Biochim. biophys. Acta328, 383–390 (1973).
A.J. Bailey, S. Bazin, M. Le Lous, C. Nicoletis and A. Delaunay,Characterization of the collagen of human hypertrophic and normal scars, Biochim. biophys. Acta405, 412–421 (1975).
A.J. Bailey, C.M. Peach and L.J. Fowler,Chemistry of the collagen cross-links, Bioch. J.117, 819–831 (1970).
A.J. Bailey and S.P. Robins,Embryonic skin collagen: replacement of the type of aldimine cross-links during the early growth period, F.E.B.S. Letters21, 330–333 (1972).
S. Bazin and A. Delaunay,Biochimie de l'Inflammation. VI. Fluctuations du taux du collagène et des protéines non fibrillaires dans différents types de foyers inflammatoires, Ann. Inst. Pasteur107, 163–172 (1964).
S. Bazin and A. Delaunay,Variations de l'activité collagénolytique dans des foyers inflammatoires en évolution, Ann. Inst. Pasteur110, 347–354 (1966).
S. Bazin and A. Delaunay,The properties of collagen in tissues of penicillamine treated rats, in:Chemistry and Molecular Biology of the Intercellular Matrix, vol. 1 (Ed. E.A. Balazs; Academic Press, 1970), p. 449–456.
S. Bazin and A. Delaunay,Biochimie de l'Inflammation. IX. Etude chimique et physiologique de deux cathepsines isolées de foyers inflammatoires, Ann. Inst. Pasteur120, 50–61 (1971).
S.M. Fitch, M.L.H. Harkness and R.D. Harkness,Extraction of collagen from tissues, Nature176, 163–164 (1955).
J.F. Woessner and R.J. Boucek,Connective tissue development in subcutaneously implanted polyvinyl sponge. I. Biochemical changes during development. Arch. Biochem. Biophys.93, 85–94 (1961).
J.F. Woessner and J.N. Ryan,Collagenase activity in homogenates of the involuting rat uterus, Biochem. biophys. Acta309, 397–405 (1973).
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Bazin, S., Le Lous, M. & Delaunay, A. Collagen in Granulation tissues. Agents and Actions 6, 272–276 (1976). https://doi.org/10.1007/BF01972221
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DOI: https://doi.org/10.1007/BF01972221