Abstract
The capacity of immunoblasts from two sources [1] peripheral lymph nodes draining the site of application of a contact sensitizer and [2] mesenteric lymph nodes from mice infected with the gut parasiteT. spiralis to migrate to the gut and to inflamed skin sites were compared.
The peripheral lymph node blasts readily entered skin sites in a non-specific way but failed to migrate to the gut even when inflammation was induced. By contrast, the mesenteric lymph node blasts readily migrated to the gut in normal mice and in increased amounts to the gut of mice infected withT. spiralis or inflamed with oral turpentine. A small proportion of mesenteric lymph node blasts did, however, migrate, non-specifically to the skin but in much smaller amounts than peripheral lymph node blasts.
We conclude that the migration of immunoblasts to the gut has some specificity related to the source from which the cells were taken but little specificity with regard to intraluminal antigen.
Similar content being viewed by others
References
Parrott, D. M. V., and Ferguson, A.,Selective migration of lymphocytes within the mouse small intestine, Immunology26, 571 (1974).
Gowans, J. L., and Knight, E. J.,The route of recirculation of lymphocytes in the rat, Proc. R. Soc. [B]159, 257.
Ferguson, A., and Parrott, D. M. V.,The effect of antigen deprivation on thymus-dependent and thymus-independent lymphocytes in the small intestine of the mouse, Clin. exp. Immun.12, 477 (1972).
Parrott, D. M. V., and de Sousa, M. A. B.,B cell stimulation in nude (nu/nu) mice, in:Proceedings of the First International Workshop on Nude Mice (Ed. J. Rygaard and C. O. Povlsen; Gustav Fischer Verlag, Stuttgart 1974), p. 61.
Guy-Grand, D., Griscelli, C., and Vassalli, P.,The gutassociated lymphoid system: nature and properties of the large dividing cells, Eur. J. Immun.4, 435 (1974).
Craig, S. W., and Cebra, J. J.,Peyer's patches: an enriched source of precursors for IgA producing immunocytes in the rabbit, J. exp. Med.134, 188 (1971).
Parrott, D. M. V.,Morphological basis of gastrointestinal immunity, in:Immunological Aspects of the Gastrointestinal Tract and the Liver (Ed. A. Ferguson and R. N. M. MacSween; Medical and Technical Publishing Co. Ltd., 1975), in press.
Hall, J. G., Parry, D. M., and Smith, M. E.,The distribution and differentiation of lymph-borne immunoblasts after intravenous injection into syngeneic recipients, Cell Tissue Kinet.5, 269 (1972).
Parrott, D. M. V., Tilney, N. L., and Sless, F.,The different migratory characteristics of lymphocyte populations from a whole spleen transplant, Clin. exp. Immun.19, 459 (1975).
Moore, A. R., and Hall, J. G.,Evidence for a primary association between immunoblasts and small gut, Nature (Lond.)239, 161 (1972).
Halstead, T. E., and Hall, J. G.,The homing of lymphborne immunoblasts to the small gut of neonatal rats, Transplantation14, 342 (1972).
Asherson, A. L., Allwood, G. G., and Mayhew, B.,Contact sensitivity in the mouse. XI. Movement of T blasts in the draining lymph nodes to sites of inflammation, Immunology25, 485 (1973).
Griscelli, C., Vassalli, P., and McCluskey, R. T.,The distribution of large dividing lymph node cells in syngeneic recipient rats after intravenous injection, J. exp. Med.130, 1427 (1969).
Wilkinson, P. C., Russell, R., Pumphrey, R., Sless, F., and Parrott, D. M. V.,Studies of chemotaxis of lymphocytes, this volume.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Parrott, D.M.V., Rose, M.L., Sless, F. et al. Factors which determine the accumulation of immunoblasts in gut and skin. Agents and Actions 6, 32–39 (1976). https://doi.org/10.1007/BF01972183
Issue Date:
DOI: https://doi.org/10.1007/BF01972183