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Fever and survival in the rat. The effect of enhancing the cold defence response

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Summary

Continuous cooling of the spinal cord for 6 and 28 days had a probably beneficial effect on the outcome of salmonellosis in the rat, suggesting that the apparently harmful effect of high fevers is not due to the cold defence response but may rather be caused by the high body temperature.

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Authors and Affiliations

  1. Physiologisches Institut der Universität, Deutschhausstrasse 2, D-3550, Marburg, Federal Republic of Germany

    M. Banet

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  1. M. Banet
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Additional information

I thank Dr W. Mannheim from the Institute of Hygiene for kindly furnishing the cultures ofS. enteritidis. This work was supported by the Deutsche Forschungsgemeinschaft (Sonderforschungsbereich 122 and Schwerpunktprogramm Temperature-regulation und-adaptation).

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Banet, M. Fever and survival in the rat. The effect of enhancing the cold defence response. Experientia 37, 985–986 (1981). https://doi.org/10.1007/BF01971794

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