Summary
Hyp mice, a model for human X-linked hypophosphatemia, had elevated urinary cyclic AMP, cyclic GMP, and magnesium excretion compared to normal mice. The data suggest a renal origin of the urinary cyclic nucleotides. No significant differences in plasma cyclic AMP and cyclic GMP were observed between genotypes.
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This work was supported in part by research grants from The Kroc Foundation and the NIH, RR-09016.
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Kiebzak, G.M., Meyer, R.A. & Mish, P.M. Increased urinary excretion of cyclic nucleotides in X-linked hypophosphatemic (Hyp) mice. Experientia 37, 978–979 (1981). https://doi.org/10.1007/BF01971790
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DOI: https://doi.org/10.1007/BF01971790