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Effect of glucocorticoids on the appearance of gamma-glutamyl transpeptidase activity in primary cultures of adult rat hepatocytes

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Summary

Primary cultures of adult rat liver parenchymal cells showed a progressive rise of gamma-glutamyl transpeptidase (GGT) activity (E.C. 2.3.2.2.) after the first 5 days of culture. The presence of dexamethasone and other synthetic glucocorticoids in the culture medium partially prevented this increase.

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Author notes

  1. J. E. Feliu

    Present address: Servicio de Endocrinología Experimental, Clínica Puerta de Hierro, Calle San Martín de Porres, 4, Madrid-35

Authors and Affiliations

  1. Ciudad Sanitaria «La Fe», Centro de Investigación, Avda de Campanar, 21, Valencia, Spain

    J. Coloma, M. J. Gómez-Lechón, M. D. García, J. E. Feliu & J. Báguena

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  1. J. Coloma
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  2. M. J. Gómez-Lechón
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  3. M. D. García
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  4. J. E. Feliu
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  5. J. Báguena
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Additional information

Supported by a research grant (No. 12/180/76) from the Spanish Instituto Nacional de la Salud, Ministerio de Sanidad y Seguridad Social.

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Coloma, J., Gómez-Lechón, M.J., García, M.D. et al. Effect of glucocorticoids on the appearance of gamma-glutamyl transpeptidase activity in primary cultures of adult rat hepatocytes. Experientia 37, 941–943 (1981). https://doi.org/10.1007/BF01971766

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  • DOI: https://doi.org/10.1007/BF01971766

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