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Ethanol and acetaldehyde do not increase the blood-brain and blood-retinal barrier permeability to sodium fluorescein

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Summary

No extravasation of sodium fluorescein from capillaries of the cerebral cortex and retina could be demonstrated in rats during severe nonlethal ethanol and/or acetaldehyde poisoning. The results do not exclude the possibility that repeated intoxications may gradually open the blood-brain and blood-retinal barriers, but do indicate the absence of an effect during acute intoxication.

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Authors and Affiliations

  1. Research Laboratories of the State Alcohol Monopoly (Alko), Box 350, SF-00101, Helsinki 10, Finland

    M. E. Hillbom & T. M. T. Tervo

  2. Department of Anatomy, University of Helsinki, SF-00170, Helsinki 17, Finland

    M. E. Hillbom & T. M. T. Tervo

Authors
  1. M. E. Hillbom
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  2. T. M. T. Tervo
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Additional information

We are indebted to Prof. Arto Palkama for his kindness in placing the facilities of his laboratory at our disposal during his visit to USA, and also thank his personal technician Miss Ulla Jääskeläinen, who skilfully made the histological preparations.

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Hillbom, M.E., Tervo, T.M.T. Ethanol and acetaldehyde do not increase the blood-brain and blood-retinal barrier permeability to sodium fluorescein. Experientia 37, 936–938 (1981). https://doi.org/10.1007/BF01971763

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  • DOI: https://doi.org/10.1007/BF01971763

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