Skip to main content
SpringerLink
Log in

High glucose-induced enzyme activity changes in cultured cell lines established from the kidneys of Chinese hamsters with aglycosuria or spontaneous glycosuria

  • Published:
Experientia Aims and scope Submit manuscript

Summary

Chinese hamster kidney epithelial-like cells derived from highly inbred nondiabetic (AV) and diabetic (XA) genetic sublines were passaged in medium containing 100 or 400 mg/dl glucose. The effect of high medium glucose on the activities of 5 enzymes involved in glucose metabolism was followed and significant glucose-dependent difference was observed. The effects, however, were opposite in cells derived fromAV andXA sublines.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. A.Y. Chang, R.E. Noble and B.M. Wyse, Diabetes26, 1063 (1977).

    Article  CAS  PubMed  Google Scholar 

  2. A.Y. Chang, Gen. Pharmac.9, 447 (1978).

    Article  CAS  Google Scholar 

  3. R.B. Tattersall, D.A. Pyke, H.M. Ranney and J.M. Bruckheimer, New Engl. J. Med.293, 1171 (1975).

    Article  CAS  PubMed  Google Scholar 

  4. V.J. Stevens, C.A. Rouzer, V.M. Monnier and A. Cerami, Proc. natl Acad. Sci. USA75, 2918 (1978).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. C.E. Guthrow, M.A. Morris, J.F. Day, S.R. Thorpe and J.W. Baynes, Proc. natl Acad. Sci. USA76, 4258 (1979).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. H. Rosenberg, J.B. Modrak, J.M. Hassing, W.A. Al-Turk and S.J. Stohs, Biochem. biophys. Res. Commun.91, 498 (1979).

    Article  CAS  PubMed  Google Scholar 

  7. A.Y. Chang and R.E. Noble, Life Sci.26, 1329 (1980).

    Article  CAS  PubMed  Google Scholar 

  8. B.A. McVerry, C. Fisher, A. Hopp and E.R. Huehns, Lancet1, 738 (1980).

    Article  CAS  PubMed  Google Scholar 

  9. R. Dolhofer and O.H. Wieland, Diabetes29, 417 (1980).

    Article  CAS  PubMed  Google Scholar 

  10. J.A. Miller, E. Gravallese and H.F. Bunn, J. clin. Invest.65, 896 (1980).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. R.G. Spiro and M.J. Spiro, Diabetes20, 641 (1971).

    Article  CAS  PubMed  Google Scholar 

  12. A.Y. Chang and B.M. Wyse, Biochim. biophys. Acta672, 239 (1981).

    Article  CAS  PubMed  Google Scholar 

  13. A.Y. Chang and H.S. Greenberg. Biochim. biophys. Acta525, 134 (1978).

    Article  CAS  PubMed  Google Scholar 

  14. A.Y. Chang, R.E. Noble, C.S. Perry and H.S. Greenberg, Diabetologia19, 1 (1980).

    Article  Google Scholar 

  15. M.A.K. Markwell, S.M. Haas, L.L. Bieber and N.E. Tolbert, Analyt. Biochem.87, 206 (1978).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Diabetes and Atherosclerosis Research, The Upjohn Company, 49001, Kalamazoo, MI, USA

    A. Y. Chang, R. E. Noble & B. M. Wyse

Authors
  1. A. Y. Chang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. E. Noble
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. B. M. Wyse
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chang, A.Y., Noble, R.E. & Wyse, B.M. High glucose-induced enzyme activity changes in cultured cell lines established from the kidneys of Chinese hamsters with aglycosuria or spontaneous glycosuria. Experientia 37, 934–935 (1981). https://doi.org/10.1007/BF01971762

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01971762

Keywords

Search

Navigation