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Concurrent occurrence of elevated ketone body and depressed carnitine level in underfed guinea-pigs

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Summary

Food ingestion of male guinea-pigs was restricted to 10 g/day. Total carnitine content of liver of the underfed animals fell to 3.75 μmoles per liver (46.1% of control). Serum level of total carnitine was 35.0 nmoles/ml (64.4%) in the underfed animals while they developed high ketonemia, 384.2 nmoles/ml (555.2%). In ‘restricted’ animals the carnitine levels also decreased in the muscles.

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References

  1. G. Delisle and I.B. Fritz, Proc. natl Acad. Sci., USA58, 790 (1967).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. J.D. McGarry, C. Robles-Valdes and D.W. Foster, Proc. natl Acad. Sci., USA72, 4385 (1975).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. A.M. Snoswell and G.D. Henderson, Biochem. J.119, 59 (1970).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. J.D. McGarry and D.W. Foster, A. Rev. Biochem.49, 395 (1980).

    Article  CAS  Google Scholar 

  5. J.D. Hulse, S.R. Ellis and L.M. Henderson, J. biol. Chem.253, 1654 (1978).

    Article  CAS  PubMed  Google Scholar 

  6. C.W. Woodruff, M.E. cherrington, A.K. Stockell and W.J. Darby, J. biol. Chem.178, 861 (1949).

    Article  CAS  PubMed  Google Scholar 

  7. J.B. Peter, R.J. Barnard, V.R. Edgerton, C.A. Gillespie and K.E. Stempel, Biochemistry11, 2627 (1972).

    Article  CAS  PubMed  Google Scholar 

  8. D.J. Pearson, P.K. Tubbs and J.F.A. Chase, in: Methods of Enzymatic Analysis, 2nd edn, p. 1758. Ed. H.U. Bergmayer. Verlag Chemie, Weinheim 1974.

    Chapter  Google Scholar 

  9. J.D. McGarry and D.W. Foster, J. Lipid Res.17, 277 (1976).

    Article  CAS  PubMed  Google Scholar 

  10. J. Mellanby and D.H. Williamson, in: Methods of Enzymatic Analysis, 2nd edn, p. 1740. Ed. H.U. Bergmayer. Verlag Chemie, Weinheim 1974.

    Google Scholar 

  11. G. Lindstedt and S. Lindstedt, J. biol. Chem.245, 4178 (1970).

    Article  CAS  PubMed  Google Scholar 

  12. J.D. McGarry, G.F. Leatherman and D.W. Foster, J. biol. Chem.253, 4128 (1978).

    Article  CAS  PubMed  Google Scholar 

  13. G. Karpati, S. Carpenter, A.G. Engel, G. Watters, J. Allen, S. Rothman, G. Klassen and O.A. Mamer, Neurology, Minneap.25, 16 (1975).

    Article  CAS  PubMed  Google Scholar 

  14. F. Cornellio, S. Didonato, D. Peluchetti, A. Bizzi, B. Bertagnolio, A. D'Angelo and U. Wiesemann, J. Neurol. Neurosurg. Psychiat.40, 1970 (1977).

    Article  Google Scholar 

  15. G. Bouding, J. Mikol, A. Gillard and A.G. Engel, J. neurol. Sci.30, 313 (1976).

    Article  Google Scholar 

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Authors and Affiliations

  1. Biochemical Institute, University Medical School, Szigeti ut 12, H-7624, Pécs, Hungary

    A. Sandor, J. Kerner & I. Alkonyi

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  1. A. Sandor
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  2. J. Kerner
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  3. I. Alkonyi
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Sandor, A., Kerner, J. & Alkonyi, I. Concurrent occurrence of elevated ketone body and depressed carnitine level in underfed guinea-pigs. Experientia 37, 933–934 (1981). https://doi.org/10.1007/BF01971761

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  • DOI: https://doi.org/10.1007/BF01971761

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