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HPLC of cephalosporins and their oxa-derivatives

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Summary

The presence of the oxygen atom in place of the sulfur atom has significant impact on the polarity of the β-lactam derivative. This has been illustrated by direct comparison of HPLC data of 4 different cephalosporin derivatives and their oxa analogues.

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References

  1. N. Neuss, R.D. Miller, C.A. Affolder, W. Nakatsukasa, J. Mabe, L.L. Huckstep, N. De La Higuera, A.H. Hunt, J.L. Occolowitz and J.H. Gilliam, Helv. chim. Acta63, 1119 (1980).

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  2. W. Nagata, in: Penicillin fifty years after Fleming, a Royal Society Discussion Organized by Sir James Baddiley FRS and E.P. Abraham, FRS, May 1979, p. 225. The Royal Society, London.

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  3. Y. Sendo, T. Konoike, M. Murakami and M. Yoshioka, Heterocycles (1981).

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Authors and Affiliations

  1. Lilly Research Laboratories, Eli Lilly and Company, 46285, Indianapolis, Indiana, USA

    R. D. Miller, Cynthia Affolder & N. Neuss

Authors
  1. R. D. Miller
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  2. Cynthia Affolder
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  3. N. Neuss
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Additional information

Acknowledgment. We gratefully acknowledge the cooperation of Drs Yuji Sendo, Toshiro Konoike, Masayuki Murakami and Mitsuru Yoshioka of Shionogi Research Laboratories, Shionogi and Co., Ltd, Fukushima-ku, Osaka, 553, Japan, who synthesized the oxa-β-lactams and made them available for this study.

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Miller, R.D., Affolder, C. & Neuss, N. HPLC of cephalosporins and their oxa-derivatives. Experientia 37, 928–930 (1981). https://doi.org/10.1007/BF01971758

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  • DOI: https://doi.org/10.1007/BF01971758

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