Agents and Actions

, Volume 6, Issue 5, pp 602–606 | Cite as

Anti-inflammatory drugs, prostaglandins and leucocyte migration

  • J. R. Walker
  • M. J. H. Smith
  • A. W. Ford-Hutchinson
Immunosuppression and Inflammation Research Reports


The action of some non-steroidal acidic anti-inflammatory drugs, aspirin, phenylbutazone and indomethacin, in reducing leucocyte migration into the exudates of inert porous sponges implanted subdermally in the rat has been shown to be distinct from their effect in reducing the content of prostaglandins in the exudates. It is concluded that a component of the anti-inflammatory and antirheumatic actions of the drugs is concerned with a mechanism other than inhibition of prostaglandin biosynthesis.


Aspirin Prostaglandin Indomethacin Phenylbutazone Prostaglandin Biosynthesis 
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  1. [1]
    R. Flower, R. Gryglewski, K. Herbaczynska-Cedro andJ.R. Vane,Effects of Anti-Inflammatory Drugs on Prostaglandin Biosynthesis, Nature New Biol.238, 104 (1972).PubMedGoogle Scholar
  2. [2]
    S.H. Ferreira andJ.R. Vane,New Aspects of the Mode of Action of Nonsteroid Anti-Inflammatory Drugs, Ann. Rev. Pharmac.14, 57 (1974).Google Scholar
  3. [3]
    A.W. Ford-Hutchinson, M.J.H. Smith, P.N.C. Elliott, J.P. Bolam, J.R. Walker, A.A. Lobo, J.K. Badcock, A.J. Colledge andF.J. Billimoria,Effects of a Human Plasma Fraction on Leucocyte Migration into Inflammatory Exudates, J. Pharm. Pharmac.27, 106 (1975).Google Scholar
  4. [4]
    A. Blackham andR.T. Owen,Prostaglandin Synthetase Inhibitors and Leucocyte Emigration, J. Pharm. Pharmac.27, 201 (1975).Google Scholar
  5. [5]
    M. Di Rosa, J.M. Papadimitriou andD.A. Willoughby,A Histopathological and Pharmacological Analysis of the Mode of Action of Nonsteroidal Anti-Inflammatory Drugs, J. Path.105, 239 (1971).PubMedGoogle Scholar
  6. [6]
    R. Vinegar, J.F. Truax andJ.L. Selph,Some Quantitative Temporal Characteristics of Carrageenin-Induced Pleurisy in the Rat, Proc. Soc. exp. Biol. Med.143, 711 (1973).PubMedGoogle Scholar
  7. [7]
    H.Z. Movat, D.R.L. Macmorine andY. Takeuchi,The Role of PMN-leucocyte Lysosomes in Tissue Injury, Inflammation and Hypersensitivity. VIII, Mode of Action and Properties of Vascular Permeability Factors Released by PMN Leucocytes during in vitro Phagocytosis, Int. Arch. Allergy40, 218 (1971).PubMedGoogle Scholar
  8. [8]
    G.A. Higgs andL.J.F. Youlten,Prostaglandin Production by Rabbit Peritoneal Polymorphonuclear Leucocytes in vitro, Br. J. Pharmac.44, 330P (1972).Google Scholar
  9. [9]
    T.J. Williams andJ. Morley,Prostaglandins as Potentiators of Increased Vascular Permeability in Inflammation, Nature246, 215 (1973).PubMedGoogle Scholar
  10. [10]
    S. Moncada, S.H. Ferreira andJ.R. Vane,Prostaglandins, Aspirin-Like Drugs and the Oedema of Inflammation, Nature246, 217 (1973).PubMedGoogle Scholar
  11. [11]
    G. Kaley andR. Weiner,Prostaglandin E 1 : A Potential Mediator of the Inflammatory Response, Ann. N.Y. Acad. Sci.180, 338 (1971).PubMedGoogle Scholar
  12. [12]
    E. McCall andL.J.F. Youlten,Prostaglandin E 1 Synthesis by Phagocytosing Rabbit Polymorphonuclear Leucocytes: Its Inhibition by Indomethacin and Its Role in Chemotaxis, J. Physiol.234, 98 (1973).Google Scholar
  13. [13]
    S.R. Turner, J.A. Campbell andW.S. Lynn,Polymorphonuclear Leukocyte Chemotaxis toward Oxidised Lipid Components of Cell Membranes, J. exp. Med.141, 1437 (1975).PubMedGoogle Scholar
  14. [14]
    G.A. Higgs, E. McCall andL.J.F. Youlten,A Chemotactic Role for Prostaglandins Released from Polymorphonuclear Leucocytes during Phagocytosis, Br. J. Pharmac.53, 539 (1975).Google Scholar
  15. [15]
    E. McCall andL.J.F. Youlten,The Effect of Indomethacin and Depletion of Complement on Cell Migration and Prostaglandin Levels in Carrageenin-Induced Air Bleb Inflammation, Br. J. Pharmac.52, 452P (1974).Google Scholar
  16. [16]
    A.W. Ford-Hutchinson, M.J.H. Smith andJ.R. Walker,Chemotactic Activity of Solutions of Prostaglandin E 1, Br. J. Pharmac.56, 345P (1976).Google Scholar
  17. [17]
    J.E. Shaw, S.J. Jessup andP.W. Ramwell,Prostaglandin-Adenyl Cyclase Relationships, in:Advances in Cyclic Nucleotide Research, vol. 1 (Raven Press, New York 1972), p. 479.Google Scholar
  18. [18]
    A.W. Ford-Hutchinson, M.J.H. Smith andJ.R. Walker,Effects of Indomethacin on Prostaglandin Levels and Leucocyte Migration in an Inflammatory Exudate in vivo, Br. J. Pharmac., Abstract in press (1976).Google Scholar
  19. [19]
    J.R. Walker, M.J.H. Smith, A.W. Ford-Hutchinson andF.J. Billimoria,Mode of Action of an Anti-Inflammatory Fraction from Normal Human Plasma, Nature254, 444 (1975).PubMedGoogle Scholar
  20. [20]
    R.J. Flower, H.S. Cheung andD.W. Cushman,Quantitative Determination of Prostaglandins and Malondialdehyde Formed by the Arachidonate Oxygenase (Prostaglandin Synthetase) System of Bovine Seminal Vesicle, Prostaglandins4, 325 (1973).PubMedGoogle Scholar
  21. [21]
    J.R. Vane,A Sensitive Method for the Assay of 5-Hydroxytryptamine, Br. J. Pharmac.12, 344 (1957).Google Scholar
  22. [22]
    J.P. Bolam, A.W. Ford-Hutchinson, P.N.C. Elliott andM.J.H. Smith,Effects of a Human Plasma Fraction on Skin Reactions in the Rat and Rabbit, J. Pharm. Pharmac.26, 660 (1974).Google Scholar
  23. [23]
    M.J.H. Smith, A.W. Ford-Hutchinson, P.N.C. Elliott andJ.P. Bolam,Prostaglandins and the Anti-Inflammatory Activity of a Human plasma Fraction in Carrageenin-Induced Paw Oedema in the Rat, J. Pharm. Pharmac.26, 692 (1974).Google Scholar
  24. [24]
    M.J.H. Smith andA.W. Ford-Hutchinson,An Anti-Inflammatory Substance in Normal Human Plasma, Agents and Actions5/4, 318 (1975).PubMedGoogle Scholar
  25. [25]
    J.R. Vane,Inhibition of Prostaglandin Biosynthesis as the Mechanism of Action of Aspirinlike Drugs, Adv. Biosci.9, 395 (1973).Google Scholar
  26. [26]
    P.L. Boardman andF.D. Hart,Clinical Measurement of the Anti-Inflammatory Effects of Salicylate in Rheumatoid Arthritis, Br. Med. J.4, 264 (1967).PubMedGoogle Scholar
  27. [27]
    R. Vinegar, A.W. Macklin, J.F. Truax andJ.L. Selph,Formation of Pedal Oedema in Normal and Granulocytopenic Rats, in:White Cells in Inflammation (Ed. C.G. Van Arnam; Thomas, Springfield, USA 1974), p. 111.Google Scholar
  28. [28]
    M.J.H. Smith, A.W. Ford-Hutchinson andP.N.C. Elliott,Prostaglandins and the Anti-Inflammatory Activities of Aspirin and Sodium Salicylate, J. Pharm. Pharmac.27, 473 (1975).Google Scholar
  29. [29]
    M.J.H. Smith,Prostaglandins and Aspirin: An Alterative View, Agents and Actions5/4, 315 (1975).PubMedGoogle Scholar
  30. [30]
    I.L. Bonta, H. Chrispijn, J. Noordhoek andJ.E. Vincent,Reduction of Prostaglandin-Phase in Hind-Paw Inflammation and Partial Failure of Indomethacin to Exert Anti-Inflammatory Effect in Rats on Essential Fatty Acid Deficient Diet, Prostaglandins5, 495 (1974).PubMedGoogle Scholar
  31. [31]
    P.G. Dellow andT.S. Miles,Meiosis: A Prostaglandin Response that is Not Inhibited by Aspirin, Br. J. Pharmac.55, 157 (1975).Google Scholar

Copyright information

© Birkhäuser-Verlag 1976

Authors and Affiliations

  • J. R. Walker
    • 1
  • M. J. H. Smith
    • 1
  • A. W. Ford-Hutchinson
    • 1
  1. 1.Department of Biochemical PharmacologyKing's College Hospital Medical SchoolLondon

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