Agents and Actions

, Volume 6, Issue 5, pp 602–606 | Cite as

Anti-inflammatory drugs, prostaglandins and leucocyte migration

  • J. R. Walker
  • M. J. H. Smith
  • A. W. Ford-Hutchinson
Immunosuppression and Inflammation Research Reports

Abstract

The action of some non-steroidal acidic anti-inflammatory drugs, aspirin, phenylbutazone and indomethacin, in reducing leucocyte migration into the exudates of inert porous sponges implanted subdermally in the rat has been shown to be distinct from their effect in reducing the content of prostaglandins in the exudates. It is concluded that a component of the anti-inflammatory and antirheumatic actions of the drugs is concerned with a mechanism other than inhibition of prostaglandin biosynthesis.

Keywords

Aspirin Prostaglandin Indomethacin Phenylbutazone Prostaglandin Biosynthesis 

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Copyright information

© Birkhäuser-Verlag 1976

Authors and Affiliations

  • J. R. Walker
    • 1
  • M. J. H. Smith
    • 1
  • A. W. Ford-Hutchinson
    • 1
  1. 1.Department of Biochemical PharmacologyKing's College Hospital Medical SchoolLondon

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