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Research in Experimental Medicine

, Volume 165, Issue 3, pp 199–203 | Cite as

Zur Prophylaxe akuter Schleimhauterosionen im Rattenmagen mit Vitamin A

  • D. Inthorn
  • V. Zumtobel
  • F. W. Schildberg
  • G. Ermann
Article

Zusammenfassung

Die protektive Wirkung von Vitamin A gegenüber stressinduzierten Ulcerationen der Magenschleimhaut wurde im Hypoxie-Stress der Ratte untersucht.

Die Zahl der akuten Schleimhauterosionen im Hauptmagen der Tiere wurde durch vor oder zu Stressbeginn intramuskulär verabreichte Vitamin A-Gaben von 125 000 – 500 000 E/kg KG signifikant vermindert.

Eine geringere Dosierung oder die Verabreichung 2 Stunden nach Stressbeginn beeinflußte die Entstehung von akuten Schleimhauterosionen nicht mehr.

Schlüsselwörter

Hypoxie-Stress Stressulcus Vitamin A-Schutzeffekt 

Prophylaxis of acute gastric erosions with vitamin A in the rat

Summary

The protective effect of Vitamin A against stress-induced ulcerations of the gastric mucosa was investigated by the hypoxic stress model of the rat.

The incidence of acute mucosal erosions in the main stomach was significantly reduced by intramuscular application of 125 000 – 500 000 U Vitamin A/kg body weight prior to or immediately after the onset of stress.

A dosage smaller than that or an application 2 hours after the onset of stress had no influence on the development of the acute mucosal erosions.

Key words

hypoxic stress stressulcer Vitamin A protective effect 

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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • D. Inthorn
    • 1
  • V. Zumtobel
    • 1
  • F. W. Schildberg
    • 1
  • G. Ermann
    • 1
  1. 1.Chirurgische KlinikUniversität MünchenMünchen 2Bundesrepublik Deutschland

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