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Comparative activity of meropenem (SM-7338) against major respiratory pathogens and amikacin-resistant nosocomial isolates

  • New Antimicrobial Agent
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Abstract

Meropenem, a new broad-spectrum carbapenem antibiotic, demonstrated excellent in vitro activity against major respiratory pathogens includingMoraxella catarrhalis, Haemophilus influenzae andStreptococcus pneumoniae. Minimal inhibitory concentrations of meropenem forMoraxella catarrhalis andHaemophilus influenzae isolates were frequently less than those of imipenem. For nosocomial amikacin-resistant gram-negative bacilli, meropenem had eightfold lower MIC90 values compared to imipenem against strains ofSerratia marcescens, Enterobacter cloacae andEscherichia coli; it was 32-fold more active than imipenem againstProteus mirabilis isolates. Activity was similar to that of imipenem againstPseudomonas aeruginosa isolates. Overall, meropenem showed excellent activity against common community-acquired pathogens as well as amikacin-resistant nosocomial pathogens.

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References

  1. Edwards JR, Turner PJ, Wannop C, Withnell ES, Grindey AJ, Nairn K In vitro antibacterial activity of SM-7338, a carbapenem antibiotic with stability to dehydropeptidase I. Antimicrobial Agents and Chemotherapy 1989, 33: 215–222.

    PubMed  Google Scholar 

  2. Jones RN, Aldridge KE, Allen SD, Barry AL, Fuchs PC, Gerlach EH, Pfaller MA Multicenter in vitro evaluation of SM-7338, a new carbapenem. Antimicrobial Agents and Chemotherapy 1989, 33: 562–565.

    PubMed  Google Scholar 

  3. National Committee for Clinical Laboratory Standards Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved tentative standard M7-T2. NCCLS, Villanova, PA, 1988.

    Google Scholar 

  4. Shanholtzer CJ, Peterson LR, Mohn ML, Moody JA, Gerding DN MBCs forStaphylococcus aureus as determined by macrodilution and microdilution techniques. Antimicrobial Agents and Chemotherapy 1984, 26: 214–219.

    PubMed  Google Scholar 

  5. Sumita Y, Inoue M, Mitsuhashi S In vitro antibacterial activity and beta-lactamase stability of the new carbapenem SM-7338. European Journal of Clinical Microbiology and Infectious Diseases 1989, 8: 908–916.

    Google Scholar 

  6. Neu HC, Novelli A, Chin N In vitro activity and β-lactamase stability of a new carbapenem, SM-7338. Antimicrobial Agents and Chemotherapy 1989, 33: 1009–1018.

    PubMed  Google Scholar 

  7. Sentochnik DE, Eliopoulos GM, Ferraro MJ, Moellering RC Comparative in vitro activity of SM-7338, a new carbapenem antimicrobial agent. Antimicrobial Agents and Chemotherapy 1989, 33: 1232–1236.

    PubMed  Google Scholar 

  8. Voutsinas D, Mavroudis T, Avlamis A, Giamarellou H In vitro activity of meropenem, a new carbapenem, against multiresistantPseudomonas aeruginosa compared with that of other antipseudomonal antimicrobials. Journal of Antimicrobial Chemotherapy 1989, 24, Supplement A: 143–147.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Infectious Diseases, James H. Quillen College of Medicine, Box 21160A, 37614, Johnson City, Tennessee, USA

    F. Sarubbi, B. Franzus & A. Verghese

  2. Section of Infectious Diseases, Mountain Home Veterans, Affairs Medical Center, 37684, Johnson City, Tennessee, USA

    F. Sarubbi & A. Verghese

Authors
  1. F. Sarubbi
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  2. B. Franzus
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  3. A. Verghese
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Sarubbi, F., Franzus, B. & Verghese, A. Comparative activity of meropenem (SM-7338) against major respiratory pathogens and amikacin-resistant nosocomial isolates. Eur. J. Clin. Microbiol. Infect. Dis. 11, 65–68 (1992). https://doi.org/10.1007/BF01971276

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  • DOI: https://doi.org/10.1007/BF01971276

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