Skip to main content
SpringerLink
Log in

Immediate and long-term efficacy of systemic antibiotics for eradicating nasal colonization withStaphylococcus aureus

  • Notes
  • Published:
European Journal of Clinical Microbiology and Infectious Diseases Aims and scope Submit manuscript

Abstract

The efficacy of nine antibiotics used in different nonrandomized regimens for eradicating nasal colonization withStaphylococcus aureus was investigated in 72 patients. Dicloxacillin, erythromycin and three cephalosporins had eradicated colonization in about 75 % of cases at early follow-up (≤20 days) and in ≤50 % at late follow-up (≥20 days). Clindamycin had eradicated colonization in all 13 patients at both follow-up times. One of two patients was successfully treated with fleroxacin, as were three of five with enoxacin. Among 21 patients treated with ofloxacin, colonization was eradicated in 20 (95 %) at early follow-up and in all six of those from whom late follow-up cultures were obtained. Thus, clindamycin and ofloxacin appear to be useful systemic antibiotics for eradicating nasal colonization withStaphylococcus aureus.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Chow JW, Yu VL Staphylococcus aureus nasal carriage in hemodialysis patients. Its role in infection and approaches to prophylaxis. Archives of Internal Medicine 1989, 149: 1258–1262.

    PubMed  Google Scholar 

  2. Luzar MA, Coles GA, Faller B, Slingeneyer A, Dah GD, Briat C, Wone C, Knefati Y, Kessler M, Peluso F Staphylococcus aureus: nasal carriage and infection in patients on continuous ambulatory peritoneal dialysis. New England Journal of Medicine 1990, 322: 505–509.

    PubMed  Google Scholar 

  3. Casewell MW, Hill RLR The carrier state: methicillin-resistantStaphylococcus aureus. Journal of Antimicrobial Chemotherapy 1986, 18, Supplement A: 1–12.

    Google Scholar 

  4. Wheat LJ, Kohler RB, White A Treatment of nasal carriers of coagulase-positive staphylococci. In: Maibach HI, Aly R (ed): Skin microbiology. Relevance to clinical infection. Springer-Verlag, New York, 1981, p. 50–58.

    Google Scholar 

  5. Cederna JE, Terpenning MS, Ensberg M, Bradley SF, Kauffman CA Staphylococcus aureus nasal colonization in a nursing home: eradication with mupirocin. Infection Control and Hospital Epidemiology 1990, 11: 13–16.

    PubMed  Google Scholar 

  6. Wheat LJ, Kohler RB, Luft FC, White A Long-term studies of the effect of rifampin on nasal carriage of coagulase-positive staphylococci. Reviews of Infectious Diseases 1983, 5, Supplement 3: 459–462.

    Google Scholar 

  7. McAnally TP, Lewis MR, Brown DR Effect of rifampin and bacitracin on nasal carriers ofStaphylococcus aureus. Antimicrobial Agents and Chemotherapy 1984, 25: 422–426.

    PubMed  Google Scholar 

  8. Wilson SZ, Martin RR, Putman M, Greenberg SB, Wallace RJ, Jemsek JG Quantitative nasal cultures from carriers ofStaphylococcus aureus: effects of oral therapy with erythromycin, rosamicin, and placebo. Journal of Antimicrobial Chemotherapy 1979, 15: 379–383.

    Google Scholar 

  9. Atmar RL, Allen ML, Freiman J, Kiefe C, Ehrman S, Greenberg SB Effect of BMY 28100, a new cephalosporin, onStaphylococcus aureus nasal carriage. European Journal of Clinical Microbiology & Infectious Diseases 1987, 6: 679–681.

    Google Scholar 

  10. Kernodle DS, Classen DC, Burke JP, Kaiser AB Failure of cephalosporins to preventStaphylococcus aureus surgical wound infections. Journal of the American Medical Association 1990, 262: 961–966.

    Google Scholar 

  11. Mulligan ME, Runae PJ, Johnston L, Wong P, Wheelock JP, McDonald K, Reinhardt JF, Johnson CC, Statner B, Blomquist I, McCarthy J, O'Brien W, Gardner S, Hammer L, Citron DM Ciprofloxacin for eradication of methicillin-resistantStaphylococcus aureus colonization. American Journal of Medicine 1987, 82, Supplement 4A: 215–219.

    PubMed  Google Scholar 

  12. Reina S, Cavallero A, Debbia E Post-antibiotic effect induced by ofloxacin in both gram-positive and gramnegative bacteria. Chemoterapia 1988, 7: 29–32.

    Google Scholar 

  13. Lewin CS, Smith JT Bactericidal mechanisms of ofloxacin. Journal of Antimicrobial Chemotherapy 1988, 22, Supplement C: 1–8.

    Google Scholar 

  14. Klempner MS, Styrt B Prevention of recurrent staphylococcal skin infections with low-dose oral clindamycin therapy. Journal of the American Medical Association 1988, 260: 2682–2685.

    PubMed  Google Scholar 

  15. Rolston KVI Clindamycin for staphylococcal skin infections in AIDS. Journal of the American Medical Association 1989, 261: 1444–1445.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. General Internal Medicine Clinic (111M), Seattle Veterans Affairs Medical Center, 1660 South Columbian Way, 98108, Seattle, WA, USA

    B. A. Lipsky

  2. Division of General Internal Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, USA

    B. A. Lipsky & R. E. Pecoraro

  3. Medical Service, Seattle Veterans Affairs Medical Center, Seattle, USA

    B. A. Lipsky, R. E. Pecoraro, J. H. Ahroni & R. L. Peugeot

Authors
  1. B. A. Lipsky
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. E. Pecoraro
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. H. Ahroni
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. L. Peugeot
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lipsky, B.A., Pecoraro, R.E., Ahroni, J.H. et al. Immediate and long-term efficacy of systemic antibiotics for eradicating nasal colonization withStaphylococcus aureus . Eur. J. Clin. Microbiol. Infect. Dis. 11, 43–47 (1992). https://doi.org/10.1007/BF01971270

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01971270

Keywords

Search

Navigation