Advertisement

Agents and Actions

, Volume 19, Issue 5–6, pp 341–343 | Cite as

Magnesium-deficient hairless rat: Spleen cells mitogenic responses and variations in hormonal status

  • A. Barbier
  • C. Planchenault
  • C. Vernhet
  • J. C. Breliere
General Inflammation

Abstract

Hairless rats with dermatosis induced with a poor magnesium diet were previously shown to bear biochemical and immunological abnormalities. It was therefore felt of interest to investigate the spleen cells proliferative responses from these rats, both in the rash and the remission phases, when testosterone and parathormone plasma levels were also determined. Results showed that proliferative responses to mitogens and PTH levels were inversely related to the intensity of the dermatosis, whereas testosterone levels were more or less decreased. The role of 1,25 dihydroxyvitamin D3 in these modifications is questionable.

Keywords

Magnesium Testosterone Plasma Level Testosterone Level Spleen Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. [1]
    C. Ponvert, L. Galoppin and J. H. Saurat,The Dermatosis of Hairless Rats Fed an Hypomagnesaemic Diet. I. Course, Clinical Features and Inhibition by Drugs. Clin. Exp. Dermatol.8, 539–547 (1983).PubMedGoogle Scholar
  2. [2]
    J. H. Saurat, P. Chavaz, A. Barbier and F. Faucher, Dermatosis in Hairless Rats fed a Low Magnesium Diet. InModels in Dermatology, vol. 1, pp. 202–209 (Eds Maibach and Lowe). Karger, Basel 1985.Google Scholar
  3. [3]
    A. Barbier, C. Planchenault, C. Vernhet and J. C. Breliere,Dermatosis in Magnesium-Deficient Hairless Rats: Effects of Steroidal and Non-Steroidal Antiinflammatory Drugs. Agents and Actions17, 352–354 (1985).Google Scholar
  4. [4]
    L. Bradley,Cell Proliferation. InSelected Methods in Cellular Immunology, pp. 153–172 (Eds B. Mishell and S. Shiigi). Freeman and Co., San Francisco, 1980.Google Scholar
  5. [5]
    T. Gunther and R. Averdunk,Reduced Lectin Stimulation of Lymphocytes in Magnesium Deficiency. J. Clin. Chem. Clin. Biochem.17, 51–55 (1979).PubMedGoogle Scholar
  6. [6]
    C. Grossman,Interactions Between the Gonadal Steroids and the Immune System. Science227, 257–261 (1985).PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1986

Authors and Affiliations

  • A. Barbier
    • 1
  • C. Planchenault
    • 1
  • C. Vernhet
    • 1
  • J. C. Breliere
    • 1
  1. 1.Sanofi ResearchClin-Midy Research CenterMontpellierFrance

Personalised recommendations