Abstract
Joint inflammation was induced in mice by cloned helper T cells specific for methylated bovine serum albumin (mBSA). This occurred after local injection of the helper T cells together with mBSA into the knee joint, but also when the helper T cells were intravenously injected and the antigen directly into the joint.
Local injection of mBSA several weeks after waning of a joint inflammation induced by cloned helper T cells caused a flare-up reaction, indicating that the helper T cells persisted in the joint after the primary inflammation.
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Klasen, I.S., Donselaar, I.G., Ladestein, R.M.T. et al. Joint inflammations and flare-up reactions in mice induced by a helper T cell clone. Agents and Actions 19, 331–334 (1986). https://doi.org/10.1007/BF01971242
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DOI: https://doi.org/10.1007/BF01971242