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, Volume 19, Issue 5–6, pp 311–312 | Cite as

Effect of (chloro-4-phenyl) thiomethylene bisphosphonic acid (SR 41319) on the autoimmune disease activity in MRL/1 mice

  • A. Barbier
  • C. Planchenault
  • J. C. Breliere
Autoimmune Models of Tissue Destruction
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Abstract

MRL-lpr/lpr (MRL/1) mice spontaneously develop an autoimmune pathology including arthritic lesions. SR 41319, a bisphosphonate, having previously shown to be active inin vitro andin vivo models of arthritis, the aim of this study was to search for its possible effect on the pathology of the MRL/1 mice. Results showed that SR 41319 reduced the severity of the disease in its early stages and increased mean life span. Further investigation would be necessary to define the effect of the drug during later stages when major changes in immune status occurred.

Keywords

Arthritis Autoimmune Disease Life Span Bisphosphonate Major Change 

References

  1. [1]
    B. Andrews, R. Eisenberg, A. Theofilopoulos, S. Izui, C. Wilson, P. McConahey, E. Murphy, J. Roths and F. Dixon,Spontaneous Murine Lupus-like Syndromes. J. Exp. Med.148, 1198–1215 (1978).CrossRefPubMedGoogle Scholar
  2. [2]
    L. Hang, A. Theofilopoulos and F. Dixon,A Spontaneous Rheumatoid Arthritis-like Disease in MRL/1 Mice. J. Exp. Med.155, 1690–1701 (1982).CrossRefPubMedGoogle Scholar
  3. [3]
    R. Roncucci, A. Barbier, J. C. Breliere and X. Emonds-Alt, Recent Advances in the Field of Remission-inducing Drugs for Arthritis. InAdvances in Inflammation Research, vol. 10, pp. 381–384 (Eds F. Russo-Marie, J. M. Mencia-Huerta and M. Chignard). Raven Press, New York 1986.Google Scholar
  4. [4]
    T. Stim, F. Persico and T. Garrabrant,Erythrocyte Sedimentation Rate Quantitation in MRL/MpM-lpr/lpr Mice. Immunopharmacology8, 171–174 (1984).CrossRefPubMedGoogle Scholar
  5. [5]
    A. Pataki and C. Rordof-Adam,Polyarthritis in MRL lpr/lpr Mice. Rheumatol. Int.5, 113–120 (1985).CrossRefPubMedGoogle Scholar
  6. [6]
    D. Clark, B. Cinader, K. Rosenthal, S. Koh and A. Chaput,Strain-dependence and Cellular Aspects of the Acceleration of Age-dependent Shift in Class-specific Helper and Suppressor Activity in the Thymus of MRL/Mp Mice by the LPR Gene. Cellular Immunology96, 418–429 (1985).CrossRefPubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1986

Authors and Affiliations

  • A. Barbier
    • 1
  • C. Planchenault
    • 1
  • J. C. Breliere
    • 1
  1. 1.Sanofi ResearchClin-Midy Research CenterMontpellierFrance

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