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Molecular genetics of murine lupus

  • Autoimmune Models of Tissue Destruction
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References

  1. A. N. Theofilopoulos and F. J. Dixon,Models of Systemic Lupus Erythematosus. InAdvances in Immunology, Vol. 37. Academic Press, 1985, pp. 269–390.

  2. R. A. Eisenberg, S. Izui, P. J. McConahey, L. M. Hang, C. J. Peters, A. N. Theofilopoulos and F. J. Dixon,Male determined accelerated autoimmune disease in BXSB mice: Transfer by bone marrow and spleen cells. J. Immunol.125, 1032–1036 (1980).

    PubMed  Google Scholar 

  3. J. E. Morton and B. V. Siegel,Transplantation of autoimmune potential. I. Development of anti-nuclear antibodies in H-2 histocompatible recipients of bone marrow from New Zealand Black mice. Proc. Natl. Acad. Sci. USA,71, 2162–2165 (1974).

    PubMed  Google Scholar 

  4. M. Akizuki, J. P. Reeves and A. D. Steinberg,Expression of autoimmunity by NZB/NZW marrow. Clin. Immunol. Immunopathol.10, 247–250 (1978).

    Article  PubMed  Google Scholar 

  5. S. Ikehara, R. A. Good, T. Nakamura, K. Sekita, S. Inoue, M. M. Oo, E. Muso, K. Oawa and Y. Hamashima,Rationale for bone marrow transplantation in the treatment of autoimmune diseases. Proc. Natl. Acad. Sci. USA82, 2483–2487 (1985).

    PubMed  Google Scholar 

  6. A. N. Theofilopoulos, D. L. Shawler, R. A. Eisenberg and F. J. Dixon,Splenic immunoglobulin secreting cells and their regulation in autoimmune mice. J. Exp. Med.151, 446–466. (1980).

    Article  PubMed  Google Scholar 

  7. G. J. Prud'homme, R. S. Balderas, F. J. Dixon and A. N. Theofilopoulos,B cell dependence on and response to accessory signals in murine lupus strains. J. Exp. Med.157, 1815–1817 (1983).

    Article  PubMed  Google Scholar 

  8. G. J. Prud'homme, C. L. Park, T. M. Fieser, R. Kofler, F. J. Dixon and A. N. Theofilopoulos,Identification of a B-cell differentiation factor(s) spontaneously produced by proliferating T cells in murine lupus strains of lpr/lpr genotype. J. Exp. Med.157, 730–742 (1983).

    Article  PubMed  Google Scholar 

  9. A. D. Steinberg, J. B. Roths, E. D. Murphy, R. T. Steinbert and E. S. Raveche,Effects of thymectomy or androgen administration upon the autoimmune disease of MRL/Mp-lpr/lpr mice. J. Immunol.125, 871–873 (1980).

    PubMed  Google Scholar 

  10. A. N. Theofilopoulos, R. S. Balderas, D.L. Shawler, S. Lee and F. J. Dixon,The influence of thymic genotype on the SLE-like disease and T cell proliferation of MRL/Mp-lpr/lpr mice. J. Exp. Med.153, 1405–1414 (1981).

    Article  PubMed  Google Scholar 

  11. D. Wofsy and W. E. Seaman,Successful treatment of autoimmunity in NZB/NZW F1 mice with monoclonal antibody to L3T4. J. Exp. Med.161, 378–391 (1985).

    Article  PubMed  Google Scholar 

  12. L. M. Hang, M. T. Aguado, F. J. Dixon and A. N. Theofilopoulos,Induction of severe autoimmune disease in normal mice by simultaneous action of multiple immunostimulators. J. Exp. Med.161, 423–428 (1985).

    Article  PubMed  Google Scholar 

  13. L. M. Hang, J. H. Slack, C. Amundson, S. Izui, A. N. Theofilopoulos and F. J. Dixon,Induction of murine autoimmune disease by chronic polyclonal B cell activation. J. Exp. Med.157, 874–883 (1983).

    Article  PubMed  Google Scholar 

  14. R. Kofler, R. M. Perlmutter, D. J. Noonan, F. J. Dixon and A. N. Theofilopoulos,The immunoglobulin heavy chain variable region gene complex of lupus mice exhibits normal restriction fragment length polymorphism. J. Exp. Med.162, 346–351 (1985).

    Article  PubMed  Google Scholar 

  15. P. H. Brodeur and R. Riblet,The immunoglobulin heavy chain variable region (Igh-V) locus in the mouse. I. Onehundred Igh-V genes comprise 7 families of homologous genes. Eur. J. Immunol.14, 922–930 (1984).

    PubMed  Google Scholar 

  16. E. Winter, A. Radbruch and W. Krawinkel,Members of novel VH gene families are found in VDJ regions of polyclonally activated beta-lymphocytes. EMBO J.4, 2861–2867 (1985).

    PubMed  Google Scholar 

  17. M. W. Steward and F. C. Hay,Changes in immunoglobulin class and subclass of anti-DNA antibodies with increasing age in NZB/W F1 hybrid mice. Clin. Exp. Immunol.26, 363–370 (1976).

    PubMed  Google Scholar 

  18. R. Papoian, R. Pillarisetty and N. Talal,Immunological regulation of spontaneous antibodies to DNA and RNA. II. Sequential switch from IgM to IgG in NZB/NZW F1 mice. Immunology32, 75–79 (1977).

    PubMed  Google Scholar 

  19. J. H. Slack, L. M. Hang, J. Barkley, F. J. Fulton, L. D'Hoostelaere, A. Robinson and F. J. Dixon,Isotypes of spontaneous and mitogen-induced autoantibodies in SLE-prone mice. J. Immunol.132, 1271–1275 (1984).

    PubMed  Google Scholar 

  20. A. N. Theofilopoulos, G. J. Prud'homme, T. M. Fieser and F. J. Dixon,B cell hyperactivity in lupus. I. Immunological abnormalities in lupus-prone strains and the activation of normal B cells. Immunol. Today4, 287–291 (1983).

    Article  Google Scholar 

  21. A. N. Theofilopoulos, G. J. Prud'homme, T. M. Fieser and F. J. Dixon,B cell hyperactivity in lupus. II. Defects in response and production of accessory signals in lupus-prone mice. Immunol. Today4, 317–319 (1983).

    Article  Google Scholar 

  22. R. Kofler, D. J. Noonan, D. E. Levy, M. C. Wilson, N. P. H. Moller, F. J. Dixon and A. N. Theofilopoulos,Genetic elements utilized for a murine lupus anti-DNA autoantibody are closely related to those for antibodies to exogenous antigens. J. Exp. Med.161, 805–815 (1985).

    Article  PubMed  Google Scholar 

  23. R. Kofler, D. J. Noonan, R. Strohal, R. S. Balderas, N. P. H. Moller, F. J. Dixon and A. N. Theofilopoulos,Three murine lupus-associated autoantibodies are structurally and clonally unrelated. Eur. J. Immunol. (in press)

  24. D. Eilat, M. Hochberg, J. Pumphrey and S. Rudikoff,Monoclonal antibodies to DNA and RNA from NZB/NZW F1 mice: Antigenic specificities and NH2 terminal amino acid sequences. J. Immunol.133, 489–494 (1984).

    PubMed  Google Scholar 

  25. Y.-H. Chien, N. R. J. Gascoigne, J. Kavaler, N. E. Lee and M. M. Davis,Somatic recombination in a murine T-cell receptor gene. Nature309, 322–326 (1984).

    Article  PubMed  Google Scholar 

  26. M. Malissen, K. Minard, S. Mjolsness, M. Kronenberg, J. Goverman, T. Hunkapillar, M. B. Prystowsky, Y. Yoshikai, F. Fitch, T. W. Mak and L. Hood,Mouse T cell antigen receptor: structure and organization of constant and joining gene segments encoding the beta polypeptide. Cell37, 1101–1110 (1984).

    PubMed  Google Scholar 

  27. N. R. J. Gasgoigne, Y.-H. Chien, D. M. Becker, J. Kavaler and M. M. Davis,Genomic organization and sequence of T cell receptor beta-chain constant- and joining-region genes. Nature310, 387–391 (1984).

    Article  PubMed  Google Scholar 

  28. J. Kavaler, M. M. Davis and Y.-H. Chien,Localization of a T cell receptor diversity-region element. Nature310, 421–423 (1984).

    Article  PubMed  Google Scholar 

  29. G. Siu, M. Kronenberg, E. Strauss, R. Harrs, T. W. Mak and L. Hood,The structure, rearrangement and expression of D-beta gene segments of the murine T-cell antigen receptor. Nature311, 344–350 (1984).

    Article  PubMed  Google Scholar 

  30. M.A. Behlke, D.G. Spinella, H.S. Chou, W. Sha, D. L. Hartl and D.Y. Loh,T cell receptor beta-chain expression: dependence on relatively few variable region genes. Science229, 566–570 (1985).

    PubMed  Google Scholar 

  31. R. K. Barth, B. S. Kim, N. C. Lan, T. Hunkapiller, N. Sobieck, A. Winoto, H. Gershenfeld, C. Okada, D. Hansburg, I. L. Weissman and L. Hood,The murine T-cell receptor uses a limited repertoire of expressed V-beta gene segments. Nature316, 517–523 (1985).

    Article  PubMed  Google Scholar 

  32. M. Kronenberg, J. Goverman, R. Haars, M. Malissen, E. Kraig, L. Phillips, T. Delovitch, N. Suciu-Foca and L. Hood,Rearrangement and transcription of the beta chain genes of the T cell antigen receptor in different types of murine lymphocytes. Nature313, 647–653 (1985).

    PubMed  Google Scholar 

  33. A. C. Hayday, D. J. Diamond, G. Tanigawa, J. J. Heilig, V. Folsom, H. Saito and S. Tonegawa,Unusual organization and diversity of T-cell receptor alpha-chain genes. Nature316, 828–832 (1985).

    Article  PubMed  Google Scholar 

  34. A. Winoto, S. Mjolsness and L. Hood,Genomic organization of the genes encoding mouse T-cell receptor alphachain. Nature316, 832–836 (1985).

    Article  PubMed  Google Scholar 

  35. D.M. Becker, P. Patten, Y.-H. Chien, T. Yokata, Z. Eshhar, M. Giedlin, M.R.J. Gascoigne, C. Goodnow, R. Wolf, K.-I. Arai and M.M. Davis,Variability and repertoire size of T-cell receptor V-alpha gene segments. Nature317, 430–434 (1985).

    Article  PubMed  Google Scholar 

  36. B. Arden, J.L. Klotz, G. Siu and L.E. Hood,Diversity and structure of genes of the alpha family of mouse T-cell antigen receptor. Nature316, 783–787 (1985).

    Article  PubMed  Google Scholar 

  37. A. C. Hayday, H. Saito, S.D. Gillies, D.M. Dranz, G. Tanigawa, H.N. Eisen and S. Tonegawa,Structure, organization, and somatic rearrangement of T cell gamma genes. Cell40, 259–269 (1985).

    Article  PubMed  Google Scholar 

  38. D.M. Kranz, H. Saito, M. Heller, Y. Takagaki, W. Haas, H. N. Eisen and S. Tonegawa,Limited diversity of the rearranged T-cell gamma gene. Nature313, 752–755 (1985).

    Article  PubMed  Google Scholar 

  39. D.J. Noonan, R. Kofler, P. Singer, G. Cardenas, F. J. Dixon and A.N. Theofilopoulos,Delineation of a defect in T cell receptor beta genes of NZW mice predisposed to autoimmunity. J. Exp. Med.163, 644–664 (1986).

    Article  PubMed  Google Scholar 

  40. M.A. Robinson and T.J. Kindt,Segregation of polymorphic T-cell receptor genes in human families. Proc. Natl. Acad. Sci. USA82, 3804–3808 (1985).

    PubMed  Google Scholar 

  41. M.L. Hoover, J. Marks, J. Chipman, E. Palmer, P. Stastny and J.D. Capra,Restriction fragment length polymorphism of the gene encoding the alpha chain of the human T cell receptor. J. Exp. Med.162, 1087–1092 (1985).

    Article  PubMed  Google Scholar 

  42. B. L. Kotzin, V.L. Barr and E. Palmer,A large deletion within the T cell receptor beta-chain gene complex in New Zealand White mice. Science229, 167–171 (1985).

    PubMed  Google Scholar 

  43. A.N. Theofilopoulos, D.L. Shawler, R.S. Balderas, J. H. Elder, D.H. Katz and F.J. Dixon,Specificities of NZB anti-H-2d CML reactions: Role of Qal and retroviral gp70 antigens. J. Immunol.126, 1154–1159 (1981).

    PubMed  Google Scholar 

  44. C.H. Park, R.S. Balderas, T. Fieser, G.J. Prud'homme, F.J. Dixon and A.N. Theofilopoulos,Isotypic profiles and other fine characteristics of immune responses of SLE mice to exogenous TD- and TI-antigens. J. Immunol.130, 2161–2167 (1983).

    PubMed  Google Scholar 

  45. P.A. Singer, R.J. McEvilly, D.J. Noonan, F.J. Dixon and A.N. Theofilopoulos,Clonal diversity and T cell receptor beta-chain variable gene expression in enlarged lymph nodes of MRL-lpr/lpr lupus mice. Proc. Natl. Acad. Sci. USA83, 7018–7022 (1986).

    PubMed  Google Scholar 

  46. P. Patten, T. Yokata, J. Rothbard, Y.-H. Chien, K.-I. Arai and M.M. Davis,Structure, expression and divergence of T-cell receptor beta chain variable regions. Nature312, 40–46 (1984).

    Article  PubMed  Google Scholar 

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Theofilopoulos, A.N. Molecular genetics of murine lupus. Agents and Actions 19, 282–294 (1986). https://doi.org/10.1007/BF01971230

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