Experientia

, Volume 39, Issue 6, pp 620–622 | Cite as

Influence of the route of administration on thyrotropin-releasing hormone concentration in the mouse brain

  • T. Mitsuma
  • T. Nogimori
Article

Summary

TRH penetrates the mouse brain after i.v., i.p., i.m., oral or rectal administration. Except when TRH is administered orally, the penetration rate is about 0.2% of the total dose administered. Higher TRH contents are reached after rectal or i.m. administration.

Keywords

Total Dose Mouse Brain Hormone Concentration Penetration Rate Rectal Administration 

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References

  1. 2.
    Prange, A. J., Wilson, I. C., Alltop, P. P., and Breese, G. R., Lancet2 (1972) 99.Google Scholar
  2. 3.
    Kastin, A. J., Schalch, D. S., Ehrensing, R. H., and Anderson, R. D., Lancet2 (1972) 740.CrossRefPubMedGoogle Scholar
  3. 4.
    Huey, L. Y., Janowsky, D. S., Mandell, A. J., Judd, L. L., and Pendery, M., Psychopharmac. Serv. Cent. Bull.11 (1975) 24.Google Scholar
  4. 5.
    Sobue, I., Yamamoto, H., Konagaya, M., Iida, M., and Takayanagi, T., Lancet1 (1980) 418.CrossRefGoogle Scholar
  5. 6.
    Redding, T. W., and Schally, A. V., Endocrinology89 (1971) 1075.PubMedGoogle Scholar
  6. 7.
    Nagai, Y., Yokohama, S., Nagawa, Y., Hirooka, Y., and Nihei, N., J. Pharm. Dyn.30 (1980) 500.Google Scholar
  7. 8.
    Sakuma, M., Nakazato, F., Kimura, M., Fujiwara, M., Sato, Y., Miyai, K., and Kumahara, Y., Folia endocr. jap.49 (1973) 1186.PubMedGoogle Scholar
  8. 9.
    Mitsuma, T., Hirooka, Y., and Nihei, N., Folia endocr. jap.51 (1974) 806.Google Scholar
  9. 10.
    Mitsuma, T., Hirooka, Y., and Nihei, N., Acta endocr. Copenh.83 (1976) 225.Google Scholar
  10. 11.
    Eckman, W. W., Phair, R. D., Fenstermacher, J. D., Patlak, C. S., Kennedy, C., and Sokoloff, L., Am. J. Physiol.229 (1975) 215.PubMedGoogle Scholar
  11. 12.
    Kimelberg, H. K., Narumi, S., and Bourke, R. S., Brain Res.153 (1978) 55.CrossRefPubMedGoogle Scholar
  12. 13.
    Raporport, I., Ohno, K., and Pettgrew, K. D., Brain Res.172 (1979) 354.CrossRefPubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1983

Authors and Affiliations

  • T. Mitsuma
    • 1
  • T. Nogimori
    • 1
  1. 1.The 4th Department of Internal MedicineAichi Medical UniversityNagakute, AichiJapan

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