Abstract
A long-term study was conducted to determine the rate of re-emergence of throat carriage of meningococci in a semi-closed kibbutz community after the administration of chemoprophylaxis to all its members. Serotype B:4 was selected as marker organism since it was isolated from a fatal case and was the most frequently occurring strain (80 %) among serogroup B isolates, which themselves comprised 54 % of all meningococci. The carriage rate among Israeli residents (volunteer workers were analyzed separately) before treatment was 6.6 % (49/748) overall, with 4.3 % group B strains. Three weeks after treatment, in most cases with rifampicin (whereby three persistently positive persons were retreated with minocycline), no meningococci were recovered. Six months later, 1.9 % of a population sample aged ≤30 years were positive, while before treatment and one and three years later, 9.4 %, 8.6 % and 4.6 % respectively were positive in this age group. Serotype B:4 comprised 81.3 % of group B strains before prophylaxis, 5.3 % after one year, and 28.6 % after three years, thus possibly re-establishing itself as the single dominant serotype. The marked suppression of carriage after mass chemoprophylaxis appeared to last at least six months, with the meningococcal population being re-established within a year.
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Chester TJ, Jacobson JA, Caviness EL, Wolf FS: House-to-house, community-wide chemoprophylaxis for meningococcal disease; an aggressive approach to disease prevention. American Journal of Public Health 1977, 67: 1058–1062.
Nicolle LE, Postl B, Kotelewetz E, Remillard F, Bourgault AM, Albritton W, Hardin GKM, Ronald A: Chemoprophylaxis forNeisseria meningitidis in an isolated Arctic community. Journal of Infectious Diseases 1982, 145: 103–109.
Dagan R, Ferne M, Sheinis M, Alkan M, Katzenelson E: An epidemic of penicillin-tolerant group A streptococcal pharyngitis in children living in a closed community: mass treatment with erythromycin. Journal of Infectious Diseases 1987, 156: 514–516.
Friedman MG, Galil A, Sarov B, Margalith M, Katzir G, Midthun K: Two sequential outbreaks of rotavirus gastroenteritis: evidence for symptomatic and asymptomatic reinfections. Journal of Infectious Diseases 1988, 158: 814–822.
Herman J, Keynan A: Long-interval transmission of meningococcal disease. Journal of Infectious Diseases 1980, 142: 945
Block C, Raz R, Efrat M, Frasch CE: Chemoprophylactic suppression of endemic carriage of group B serotype 4Neisseria meningitidis in a kibbutz community. In: Achtman M, Kohl P, Marchal C, Morelli G, Seiler A, Thiesen B (ed): Neisseriae 1990: Proceedings of the Seventh International Pathogenic Neisseria Conference. Walter de Gruyter, Berlin, 1991, p. 665–669.
Morello JA, Janda WM, Doern GV:Neisseria andBranhamella. In: Balows A, Hausler WJ, Herrmann LK, Isenberg HD, Shadomy HJ (ed): Manual of clinical microbiology. American Society for Microbiology, Washington DC, 1991, p. 258–276.
Mocca LF, Frasch CE: Sodium dodecyl sulphate-poly-acrylamide gel typing system for characterization ofNeisseria meningitidis isolates. Journal of Clinical Microbiology 1982, 16: 240–244.
Frasch CE: Development of meningococcal serotypes. In: Vedros NA (ed): Evolution of meningococcal disease. Volume 2. CRC Press, Boca Raton, 1987, p. 39–55.
Stuart JM, Cartwright KAV, Jones DM, Noah ND, Wall RJ, Blackwell CC, Jephcott AE, Ferguson IR: An outbreak of meningococcal disease in Stonehouse: planning and execution of a large-scale survey. Epidemiology and Infection 1987, 99: 579–589.
Costa W, Sacchi CT, Ramos S, Milagres L, Prigenzi LS: Meningococcal disease in Sao Paolo, Brazil. NIPH Annals 1991, 14: 215–216.
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Block, C., Raz, R., Frasch, C.E. et al. Re-emergence of meningococcal carriage on three-year follow-up of a kibbutz population after whole-community chemoprophylaxis. Eur. J. Clin. Microbiol. Infect. Dis. 12, 505–511 (1993). https://doi.org/10.1007/BF01970955
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DOI: https://doi.org/10.1007/BF01970955