Vitamin E-induced chronic inflammation in rats
- 17 Downloads
Sub-plantar injection of vitamin E (VE) oil produces a highly localized, chronic inflammation which is sustained for at least 8 weeks. As a result of studies using mediator inhibitors and depletors, it appears that histamine, serotonin, kinins, and prostaglandins may be involved in at least the early response to VE. This early phase is dominated by a massive influx of neutrophils, with the reaction rapidly progressing to a sustained mononuclear cell pathology. Results of studies in leucopenic rats suggest that edema formation and accumulation of white cells may be dissociable, although at this time it is not possible to conclude that edema can occur in the absence of cells since profoundly leucopenic rats are still able to locally mobilize polymorphonuclear cells in response to VE. Vitamin E-induced inflammation, produced under the conditions described, can be effectively suppressed by corticosteroids but seems relatively insensitive to the action of most non-steroidal anti-inflammatory agents tested.
KeywordsCorticosteroid Serotonin Histamine Prostaglandin Mononuclear Cell
Unable to display preview. Download preview PDF.
- E.M. Glenn, W.L. Miller andC.A. Schlagel,Metabolic Effects of Adrenocortical Steroids in Vivo and in Vitro: Relationship to Antiinflammatory Effects, Recent Progr. Hormone Res.XIX, 107–199 (1963).Google Scholar
- E.M. Glenn,Steroids, Nonsteroids, Intermediary Metabolism, Inflammation and Their Probable Interrelationships, in:Hormonal Steroids, Biochemistry, Pharmacology, and Therapeutics, Proceedings of the First International Congress on Hormonal Steroids1, 319–349 (1964).Google Scholar
- E.M. Glenn, B.J. Bowman andT.C. Koslowske,The Systemic Response to Inflammation, Biochem. Pharmacol., Suppl., 27–49. Pergamon Press, Oxford, England.Google Scholar
- J. van der Vies, R.F.M. Bakker andD. de Wied,Correlated Studies on Plasma Corticosterone and on Adrenal Steroid Formation Rate in Vitro, Acta Endocr.34, 513–523 (1960).Google Scholar
- D.J. Finney,Statistical Method in Biological Assay, Second Edition (Hafner Publishing Company, New York, 1964).Google Scholar
- L. Katz andS.J. Piliero,A Study of Adjuvant-Induced Polyarthritis in the Rat with Special Reference to Associated Immunological Phenomena, Ann. N.Y. Acad. Sci.147, 515 (1969).Google Scholar
- Practical Immunology (Eds. L. Hudson and F. Hay; Blackwell Science Publications, Oxford, London, 1976), p. 9.Google Scholar
- M. Di Rossa andL. Sorrentino,Some Pharmacodynamic Properties of Carrageenan in the Rat, Brit. J. Pharmacol.38, 214–220 (1970).Google Scholar
- P. Crunkhorn andS.C.R. Meacock,Mediators of the Inflammation Induced in the Rat Paw by Carrageenan, Brit. J. Pharmacol.42, 392–402 (1971).Google Scholar
- T. Astrup, I.B. Galsmar andM. Volkert,Polysaccharide Sulfuric Acids as Anticoagulants, Acta physiol. scand.8, 215–226 (1944).Google Scholar
- V. Eisen andC. Loveday,In Vivo Effects of Cellulose Sulfate on Plasma Kininogen, Complement and Inflammation, Brit. J. Pharmacol.42, 383–391 (1971).Google Scholar