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Pharmaceutisch Weekblad

, Volume 12, Issue 4, pp 151–153 | Cite as

Ascorbic acid prevents cimetidine-induced decrease of serum hydrocortisone concentrations

  • Marinus P. Boidin
  • Arie Stuurman
  • Wilhelm Erdmann
Articles

Abstract

A blind, parallel, prospective, clinical study was conducted to investigate the effect of ascorbic acid on human serum hydrocortisone concentrations which were decreased by the administration of cimetidine. The study population included 16 male adults scheduled for major abdominal vascular surgery. The study was conducted in surgical patients under anaesthesia, in which steroidogenesis was inhibited by cimetidine. The results showed a reduction in serum hydrocortisone concentrations in patients receiving a placebo. In patients receiving ascorbic acid, there was a significant increase in serum hydrocortisone concentration. This reflects the normal serum hydrocortisone profile for this operation and anaesthetic technique. Cimetidine can bind to cytochrome P-450 covering the active haem group, the cytochrome proves to be of vital importance for hydroxylation reactions, involved in human steroidogenesis. Serum hydrocortisone concentrations will decrease when cytochrome P-450 becomes blocked. Intravenous administration of ascorbic acid was supposed to cause relief for this decrease. The reasons are undetermined yet. This investigation proved that ascorbic acid can prevent cimetidine-induced decrease of human serum hydrocortisone concentrations.

Keywords

Ascorbic acid Cimetidine Cytochrome P-450 Hydrocortisone Metabolism Steroid hydroxylases 

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1990

Authors and Affiliations

  • Marinus P. Boidin
    • 1
  • Arie Stuurman
    • 2
  • Wilhelm Erdmann
    • 1
  1. 1.Department of AnaesthesiologyErasmus University RotterdamDR Rotterdamthe Netherlands
  2. 2.Department of Hospital PharmacyFoundation Ignatius Hospital BredaJX Bredathe Netherlands

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