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The role of hyperoxygenation in facilitating the induction of pulmonary histiocytosis by low doses of chlorphentermine

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Summary

Hyperoxygenation modified the susceptibility of neonatal rat lung to respond to chlorphentermine with an accumulation of hypertrophic macrophages, a morphologic change undetected when an anorectic drug was given alone. Implications of this observation for pediatrics are discussed.

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Authors and Affiliations

  1. Departments of Pharmacology and Anatomy, Faculty of Health Sciences, School of Medicine, University of Ottawa, KIN 9N9, Ottawa, Ontario, Canada

    S. Kacew & R. Narbaitz

Authors
  1. S. Kacew
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  2. R. Narbaitz
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Additional information

This work was supported by grants from the Medical Research Council of Canada.

Acknowledgments. Skilled technical assistance was provided by Mr V. Kapal and Miss G.A. Calderwood, Jr. The authors wish to thank Dr I.M. Nielsen, H. Lundbeck and Company. Copenhagen, Denmark, for the generous supply of chlorphentermine.

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Kacew, S., Narbaitz, R. The role of hyperoxygenation in facilitating the induction of pulmonary histiocytosis by low doses of chlorphentermine. Experientia 36, 673–675 (1980). https://doi.org/10.1007/BF01970132

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