Summary
Hypertension may be induced by pharmacologic activation of central cholinergic receptors either indirectly, through the injection i.v. of physostigmine, or directly, through the injection i.v. of arecholine in anesthetized rats. Activation of peripheral preganglionic cholinergic receptors with dimethylphenylpiperazinium iodide (DMPP) also produced a hypertensive response. Pretreatment with various doses of clonidine caused inhibition of the pressor response to central cholinergic stimulation but was without effect on the response to ganglionic cholinergic stimulation.
Similar content being viewed by others
References
H.E. Brezenoff and J. Rusin, Eur. J. Pharmac.29, 262 (1974).
J.J. Buccafusco and H.E. Brezenoff, Brain Res.165, 295 (1979).
M. Weinstock, A.P. Zavadil, C.C. Chiueh and I.J. Kopin, Life Sci.24, 301 (1979).
J.G. Nutt, A. Rosin and T. Chase, Neurology28, 1061 (1978).
B.A. Stamenovic and V.M. Varagic, Neuropharmacology9, 561 (1970).
J.J. Buccafusco, J.P.M. Finberg and S. Spector, Fedn. Proc.38, 739 (1979).
G.A. Bentley and D.M.F. Li, Eur. J. Pharmac.4, 124 (1968).
G.M. Drew, Br. J. Pharmac.64, 293 (1978).
G.J. Green, H. Wilson and M.S. Yates, Eur. J. Pharmac.53, 297 (1979).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Buccafusco, J.J., Spector, S. Influence of clonidine on experimental hypertension induced by cholinergic stimulation. Experientia 36, 671–673 (1980). https://doi.org/10.1007/BF01970131
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01970131