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Effects of repeated administration of potassium canrenoate (SC-14266) on serum gonadotrophin, prolactin, testosterone and progesterone in male rats

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Summary

Chronic administration of potassium canrenoate (SC-14266), a water-soluble anti-aldosterone agent, increased serum LH levels in male rats without altering serum levels of FSH, prolactin, testosterone and progesterone. The increase in serum LH may be due to the anti-androgenic effect of potassium canrenoate.

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Authors and Affiliations

  1. Department of Pharmacology. School of Medicine, Keio University, Shinanomachi, Shinjuku-ku, 160, Tokyo, Japan

    T. Muraki, T. Nakadate, K. Kubota, Y. Tokunaga & R. Kato

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  1. T. Muraki
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  2. T. Nakadate
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  3. K. Kubota
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  4. Y. Tokunaga
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  5. R. Kato
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Additional information

Acknowledgments. The authors thank the Rat Pituitary Hormone Distribution Program, NIAMDD, NIH and Dr A.F. Parlow for radioimmunoassay materials.

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Muraki, T., Nakadate, T., Kubota, K. et al. Effects of repeated administration of potassium canrenoate (SC-14266) on serum gonadotrophin, prolactin, testosterone and progesterone in male rats. Experientia 36, 668–669 (1980). https://doi.org/10.1007/BF01970128

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  • DOI: https://doi.org/10.1007/BF01970128

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